Evidence map›Paper›PMID 41109666›Full record

ArticleThe American journal of pathology2026

Inactivation of Atp7b Copper Transporter in Intestinal Epithelial Cells Is Associated with Altered Lipid Processing and Cell Growth Machinery Independent from Hepatic Copper Accumulation and Severity of Liver Histology.

Amanda Caceres, Noreene M Shibata, Christian D Davalos-Gutierrez, Gaurav V Sarode, Hisham Hussan, Margarida Bettencourt, Adriana Fontes, Hans Zischka, Svetlana Lutsenko, Marie C Heffern and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amanda CaceresDepartment of Chemistry, University of California Davis, Davis, California.
Noreene M ShibataDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of California Davis, Davis, California.
Christian D Davalos-GutierrezDepartment of Chemistry, University of California Davis, Davis, California.
Gaurav V SarodeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of California Davis, Davis, California.
Hisham HussanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of California Davis, Davis, California.
Margarida BettencourtDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of California Davis, Davis, California.
Adriana FontesInstitute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Toxicology and Environmental Hygiene, Technical University Munich, Munich, Germany.
Hans ZischkaInstitute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Toxicology and Environmental Hygiene, Technical University Munich, Munich, Germany.
Svetlana LutsenkoDepartment of Physiology, Johns Hopkins Medical Institutes, Baltimore, Maryland.
Marie C HeffernDepartment of Chemistry, University of California Davis, Davis, California.
Valentina MediciDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of California Davis, Davis, California. Electronic address: vmedici@ucdavis.edu.

Funding

Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Molecular Mechanisms of ATP-dependent Copper TransportersR01DK071865 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI SVETLANA LUTSENKO · 2005 to 2026
$7.9M
Neuroimmune interactions in Rett syndromeR01AA027075 · NIAAA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LASALLE, JANINE M · 2018 to 2022
$2.9M
Supplement: Metalloendocrinology: Mapping Bioinorganic Chemistry in the Extracellular SpaceR35GM133684 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HEFFERN, MARIE C. · 2019 to 2023
$2.0M
Epigenetic regulation of Wilson DiseaseR01DK104770 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MEDICI, VALENTINA · 2016 to 2020
$1.8M
NIAAA NIH HHS R01 AA027075NIDDK NIH HHS P30 DK098722NIDDK NIH HHS P30 DK116074NIDDK NIH HHS R01 DK071865NIDDK NIH HHS R01 DK104770NIGMS NIH HHS R35 GM133684
6 · The paper itself

Abstract

The clinical manifestations of Wilson disease (WD) are related to copper accumulation in the liver and brain, but little is known about the role of other organs expressing the ATP7B copper transporter on metabolic and ultrastructural changes characterizing WD. To examine the consequences of intestinal Atp7b inactivation in the absence of hepatic copper accumulation, a new mouse model (Atp7b

Indexed as

CopperCopper-Transporting ATPasesEpithelial CellsHepatolenticular DegenerationIntestinal MucosaLipid MetabolismLiverAnimalsCell ProliferationDisease Models, AnimalMiceMice, Inbred C57BLMice, KnockoutAtp7b protein, mouseCopperCopper-Transporting ATPases

Identifiers

PMID41109666
PMCPMC12881291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.