ReviewBiological psychiatry2026
Reductive Stress and Dysregulated Energy Metabolism in Schizophrenia: Mechanisms and Therapeutic Targets.
Review in Biological psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Schizophrenia: Converging Neurobiological Mechanisms and Emerging Therapeutic Strategies.Biomolecules · 2026Review
- The Reductive Stress Nexus: Integrated Pathways of Metabolic Dysregulation, Senescence and Blood-Brain Barrier Failure in Neurodegenerative Disease and Brain Aging.Cell biochemistry and biophysics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Reductive stress, defined by excessive accumulation of reducing equivalents such as NADH, disrupts cellular redox balance and is emerging as a detrimental factor in schizophrenia (SZ). It is closely related to the mitochondrial defects commonly seen in SZ, which implies its importance in impaired energy metabolism. Reductive stress intersects with oxidative stress pathways and causes an underappreciated additional burden on cellular systems. The integrated stress response (ISR) is an adaptive pathway typically activated by mitochondrial oxidative phosphorylation defects and other stressors. Emerging evidence indicates that reductive stress can independently activate the ISR. These findings highlight the crucial role of reductive stress in disease pathophysiology, although the process is not fully understood. Therefore, there is a need for innovative therapeutic approaches that can address reductive stress and mitochondrial dysfunction.
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Registered trials
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