Evidence map›Paper›PMID 41109592›Full record

ArticleExperimental eye research2025

Lamina cribrosa shape in non-human primates is different from that of humans.

Miriam Bohlmann Kunz, Ziyi Zhu, Susannah Waxman, Bo Wang, Jacob Wallace, Samantha E Schmitt, Hiroshi Ishikawa, Joel S Schuman, Matthew A Smith, Gadi Wollstein and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Miriam Bohlmann KunzDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA.
Ziyi ZhuDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA.
Susannah WaxmanDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA.
Bo WangDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jacob WallaceDepartment of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA.
Samantha E SchmittDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.
Hiroshi IshikawaDepartment of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA; Department of Medical Informatics and Clinical Epidemiology (DMICE), Oregon Health & Science University, Portland, OR, USA.
Joel S SchumanDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA; Glaucoma Service, Wills Eye Hospital, Philadelphia, PA, USA; Vickie and Jack Farber Vision Research Center, Wills Eye Hospital, Philadelphia, PA, USA; School of Biomedical Engineering, Science and Health Studies, Drexel University, Philadelphia, PA, USA; Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Matthew A SmithDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA.
Gadi WollsteinGlaucoma Service, Wills Eye Hospital, Philadelphia, PA, USA.
Ian A SigalDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: ian@OcularBiomechanics.com.

Funding

Virus Production and Manipulation of Protein/Gene Expression ModuleP30EY008098 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yuanyuan Chen · 1989 to 2026
$17.8M
Novel Glaucoma Diagnostics for Structure and Function - Renewal - 1R01EY013178 · NEI · WILLS EYE HEALTH SYSTEM · PI Joel S Schuman · 2000 to 2026
$17.5M
Optic nerve head microstructure, biomechanics and susceptibility to glaucomaR01EY023966 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ian A Sigal · 2014 to 2026
$3.8M
Interdisciplinary Visual Sciences (IVS) Traininig ProgramT32EY017271 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Marlene Behrmann, Paul R. Kinchington · 2008 to 2026
$3.6M
High-resolution Elastographic Assessment of the Optic Nerve HeadR01EY028662 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHONGPING, SIGAL, IAN A · 2018 to 2021
$2.7M
Interplay between intraocular and cerebrospinal fluid pressure effects on the optic nerve head in vivoR01EY025011 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SIGAL, IAN A, WOLLSTEIN, GADI · 2015 to 2018
$1.5M
NEI NIH HHS P30 EY008098NEI NIH HHS R01 EY013178NEI NIH HHS R01 EY023966NEI NIH HHS R01 EY025011NEI NIH HHS R01 EY028662NEI NIH HHS T32 EY017271
6 · The paper itself

Abstract

Non-human primates (NHPs) are a crucial model for studying glaucoma because of their similarities to humans in anatomy, physiology and pathology. Our goal in this study was to quantify in vivo NHP lamina cribrosa (LC) shapes at low, normal, and elevated intraocular pressures (IOPs), and compare them with literature reported values for in vivo human LCs. We imaged the optic nerve heads (ONH) of seven eyes from six rhesus macaque monkeys using spectral-domain optical coherence tomography (SD-OCT) at several IOP levels while keeping intracranial pressure at baseline. LC shape was characterized by measuring shape index (SI) and curvedness from manually delineated marks of the anterior LC surface. We found that LC shape in NHPs was more similar across individuals at normal IOP than it is in humans. This was, in part, because the NHPs LCs did not exhibit the characteristic horizontal central ridge seen in human LCs and were instead less saddle-shaped and more trough-shaped. With increasing IOP, NHPs LCs curvedness increased, without significant changes in SI, differing from the human response where SI decreases. These findings emphasize the importance of characterizing species-specific differences in anatomy and biomechanics, and the need to determine how these differences may impact susceptibility to glaucomatous damage.

Indexed as

GlaucomaOptic DiskOptic Nerve DiseasesAnimalsDisease Models, AnimalFemaleHumansIntraocular PressureMacaca mulattaMaleSpecies SpecificityTomography, Optical CoherenceBiomechanicsGlaucomaIntracranial pressureIntraocular pressureLamina cribrosaOCTOptic nerve headTranslaminar pressure

Identifiers

PMID41109592
PMCPMC13192369

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.