Evidence map›Paper›PMID 41109210›Full record

ArticleJournal of clinical periodontology2026

Volume-Stable Collagen Matrix as a Recombinant Human Bone Morphogenetic Protein-2 Carrier for Maxillary Sinus Augmentation: An Experimental In Vivo Study.

Chae-Eun Kim, Seung-Hyun Park, Kyeong-Won Paeng, Lorenzo Tavelli, David T Wu, Daniel S Thoma, Ronald E Jung, Ui-Won Jung, Jae-Kook Cha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chae-Eun KimDepartment of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, South Korea.
Seung-Hyun ParkDepartment of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, South Korea.ORCID 0000-0002-6207-8036
Kyeong-Won PaengDepartment of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, South Korea.
Lorenzo TavelliDepartment of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, USA.ORCID 0000-0003-4864-3964
David T WuDepartment of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, USA.ORCID 0000-0002-9752-5377
Daniel S ThomaDepartment of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, South Korea.ORCID 0000-0002-1764-7447
Ronald E JungClinic of Reconstructive Dentistry, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.
Ui-Won JungDepartment of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, South Korea.ORCID 0000-0001-6371-4172
Jae-Kook ChaDepartment of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, South Korea.ORCID 0000-0002-6906-7209

Funding

Korea Health Industry Development Institute HI22C1609
6 · The paper itself

Abstract

aimTo test the hypothesis that a volume-stable collagen matrix (VCMX) can serve as an effective rhBMP-2 carrier for bone regeneration while compensating for the volume instability of absorbable collagen sponge (ACS). MATERIALS AND

methods(i) rhBMP-2 release kinetics from VCMX and ACS were measured over 7 days by enzyme-linked immunosorbent assay. (ii) Bilateral sinus augmentations were performed in 15 rabbits using either VCMX or ACS, with or without rhBMP-2. After 4 weeks, radiographic and histological analyses were conducted.

resultsThe overall release patterns between VCMX and ACS did not differ significantly, although VCMX showed a delayed peak release (at 3 h) compared to ACS (at 10 min). Three-dimensional radiographic analysis showed greater volumetric gains in VCMX groups than in ACS groups, regardless of rhBMP-2 loading. Histologically, VCMX/rhBMP-2 group exhibited the largest total augmented area (13.1 ± 2.9 mm

conclusionrhBMP-2-loaded VCMX enhances bone regeneration in sinus augmentation, suggesting that its volume maintenance may contribute to the improved clinical and radiographic outcomes.

Indexed as

Bone Morphogenetic Protein 2CollagenDrug CarriersSinus Floor AugmentationTransforming Growth Factor betaAbsorbable ImplantsAnimalsBone RegenerationHumansMaleRabbitsRecombinant ProteinsBone Morphogenetic Protein 2CollagenDrug Carriersrecombinant human bone morphogenetic protein-2Recombinant ProteinsTransforming Growth Factor betaanimal experimentbone morphogenetic protein‐2sinus floor elevationvolume‐stable collagen matrix

Identifiers

PMID41109210
PMCPMC12803691

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.