Evidence map›Paper›PMID 41109040›Full record

ArticlePlacenta2025

Maternal organophosphate pesticide exposure in relation to birthweight: Modification by placenta transporter genotype.

Duong Q Nguyen, Sara Hyman, Eleanor Medley, Anne K Bozack, Linda G Kahn, Kurunthachalam Kannan, Alejandra Guitierrez, Lauren M Aleksunes, Zorimar Rivera-Núñez, Whitney Cowell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Placenta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Duong Q NguyenDepartment of Pediatrics, New York University School of Medicine, New York, NY, USA.
Sara HymanDepartment of Pediatrics, New York University School of Medicine, New York, NY, USA.
Eleanor MedleyDepartment of Population Health, New York University School of Medicine, New York, NY, USA.
Anne K BozackDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA.
Linda G KahnDepartment of Pediatrics, New York University School of Medicine, New York, NY, USA; Department of Population Health, New York University School of Medicine, New York, NY, USA.
Kurunthachalam KannanDepartment of Pediatrics, New York University School of Medicine, New York, NY, USA.
Alejandra GuitierrezJohn Hopkins Nucleic Acid Technologies, Baltimore, MD, USA.
Lauren M AleksunesDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA; Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA.
Zorimar Rivera-NúñezEnvironmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA.
Whitney CowellDepartment of Pediatrics, New York University School of Medicine, New York, NY, USA; Department of Population Health, New York University School of Medicine, New York, NY, USA. Electronic address: Whitney.Cowell@nyulangone.org.

Funding

Project-005U2COD023375 · OD · DUKE UNIVERSITY · PI Phillip Brian Smith · 2016 to 2026
$215.9M
The NYU Children’s Health & Environment Study: an ECHO CohortUH3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Akhgar Ghassabian, Leonardo Trasande · 2018 to 2026
$59.5M
Integrated Transporter Elucidation CenterUC2HD113039 · NICHD · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Lauren M Aleksunes, Dongeun Huh · 2023 to 2026
$4.5M
Impact of Phthalate Exposure on Telomere Biology in UteroR01ES035760 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ABRAHAM AVIV, Whitney Cowell · 2024 to 2026
$1.1M
Particulate air pollution, pregnancy outcomes, and the role of placental extracellular microRNAsR00ES032029 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COWELL, WHITNEY · 2022 to 2024
$745k
NICHD NIH HHS UC2 HD113039NIEHS NIH HHS R00 ES032029NIEHS NIH HHS R01 ES035760NIH HHS U2C OD023375NIH HHS UH3 OD023305
6 · The paper itself

Abstract

Exposure to organophosphate pesticides (OPPs) has been linked to adverse birth outcomes, including low birthweight. Maternal biomarkers are commonly used as proxies for fetal exposure, but fetal exposure also depends on placental transport mechanisms. In 240 mother-newborn pairs, we explored how genetic variation in membrane transporters influences the association between maternal OPP concentrations and birthweight. Single nucleotide polymorphisms (SNPs) in the OAT4/SLC22A11 and OATP2B1/SLCO2B1 membrane transporters modified the relationship between OPP exposure and birthweight-for-gestational age, with significant inverse associations observed only among individuals with variant transporter genotypes. In this small study, we found that transporter genotype may influence the placental disposition of environmental chemicals and perinatal susceptibility to toxicity.

Indexed as

Birth WeightMaternal ExposureOrganic Anion TransportersOrganophosphorus CompoundsPesticidesPlacentaAdultFemaleGenotypeHumansInfant, NewbornPolymorphism, Single NucleotidePregnancyOrganic Anion TransportersOrganophosphorus CompoundsPesticidesSLCO2B1 protein, humanBirthweightFetusGenetic polymorphismOrganophosphate pesticidesplacentaSNP

Identifiers

PMID41109040
PMCPMC12822829

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.