ArticleAdvanced materials (Deerfield Beach, Fla.)2026
Intrinsically Disordered Protein-Inspired Nanovector-Based Coacervates for the Direct Cytosolic Transport of Biomacromolecules.
Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Decoding the tactics for coacervate pedestrian crossing the phospholipid membrane.Chemical science · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
In eukaryotic cells, membraneless organelles (MLOs) are formed via liquid‒liquid phase separation (LLPS) involving intrinsically disordered proteins (IDPs) and biomacromolecules, enabling biomacromolecule transport without vesicles, transporters, or channels. Although MLO-mimetic coacervates generated from synthetic biomaterials can deliver biomacromolecules into cells, they lack the conformational adaptability of IDPs and a defined internalization mechanism, limiting their stability under physiological conditions and hindering biomedical translation. Here, IDP-inspired nanovectors (IDP-NVs) are developed with conformational adaptability capable of forming nanocoacervates (NCs) with biomacromolecules for cytosolic delivery. Mixing with IDP-NVs and cargos results in stable NCs under physiological conditions, and the NCs can directly penetrate cellular membranes through the molecular motion of IDP-NVs. After the internalization, cytoplasmic glutathione triggers NC disassembly, releasing biomacromolecules in the cytosol. The NCs effectively deliver biomacromolecules of diverse sizes, charges, shapes (globular proteins and antibodies), and functions (mRNAs and CRISPR units), demonstrating their versatility and potential for biomedical applications.
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Registered trials
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