Trial reportGeriatrics & gerontology international2025
Pre-Operative Resistance Training and Amino Acid Supplementation in Frail Patients With Gastrointestinal Cancer: A Randomized Clinical Trial.
Trial report in Geriatrics & gerontology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Pre-Operative Resistance Training and Amino Acid Supplementation in Frail Patients With Gastrointestinal Cancer: A Randomized Clinical Trial.Geriatrics & gerontology international · 2025Trial
- Impact of diabetes mellitus and grip strength on postoperative outcomes in older patients undergoing cancer surgery: A single-center retrospective cohort study.Journal of diabetes investigation · 2026Article
Corrections and comments
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Authors and funding
21 authors.
Funding
Abstract
aimTo investigate the impact of preoperative exercise and nutritional interventions on postoperative complications, physical function, and activities of daily living (ADL) 1 year postoperatively in frail older patients with gastrointestinal cancer.
methodsThis single-center, randomized controlled trial enrolled 62 patients aged ≥ 70 years scheduled to undergo elective surgery for gastrointestinal cancer with decreased grip strength or walking speed between October 2017 and December 2022. Participants were randomly assigned to control (n = 33) and intervention (n = 29) groups; the latter performed resistance exercises and consumed amino acid-containing jelly daily at home for 14 days. All participants were followed-up for 1 year.
resultsAfter exclusion, 27 and 18 patients were enrolled in the control and intervention groups, respectively. The average age was 80.4 years, and 37.8% were male. Postoperative complications were observed in 51.9% and 44.4% of the control and intervention groups, respectively (95% confidence interval [CI] 0.62-2.19), with postoperative delirium observed in 25.9% and 33.3%, respectively (95% CI 0.31-1.94). There were no significant inter-group differences in grip strength, walking speed, or skeletal muscle index. However, the intervention group showed superior knee extension strength maintenance (preoperatively: 100.2% ± 18.3% vs. 119.1% ± 68.8%, p = 0.19; discharge: 86.7% ± 22.0% vs. 119.3% ± 72.0%, p = 0.044), and lower rates of decreased ADLs or death 1 year postoperatively (42.3% vs. 23.5%; RR 0.56, 95% CI 0.08-1.92).
conclusionsThis 14-day preoperative exercise and nutritional intervention program did not significantly reduce postoperative complications in frail older patients with gastrointestinal cancer; however, it aided in maintaining knee extension strength at discharge.
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