Evidence map›Paper›PMID 41108586›Full record

ArticlePhysiological reports2025

Nicotinamide N-methyltransferase inhibition improves limb function in experimental peripheral artery disease.

Gengfu Dong, Jaewon Choi, Yufen Li, Diana C Muller, Zhuoxin Li, Yangyi E Luo, Terence E Ryan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gengfu DongDepartment of Applied Physiology and Kinesiology, The University of Florida, Gainesville, Florida, USA.
Jaewon ChoiDepartment of Applied Physiology and Kinesiology, The University of Florida, Gainesville, Florida, USA.
Yufen LiDepartment of Applied Physiology and Kinesiology, The University of Florida, Gainesville, Florida, USA.
Diana C MullerDepartment of Applied Physiology and Kinesiology, The University of Florida, Gainesville, Florida, USA.
Zhuoxin LiDepartment of Applied Physiology and Kinesiology, The University of Florida, Gainesville, Florida, USA.
Yangyi E LuoDepartment of Applied Physiology and Kinesiology, The University of Florida, Gainesville, Florida, USA.
Terence E RyanDepartment of Applied Physiology and Kinesiology, The University of Florida, Gainesville, Florida, USA.ORCID https://orcid.org/0000-0003-0780-029X

Funding

Molecular mechanisms regulating peripheral arterial disease pathobiology in chronic kidney diseaseR01HL149704 · NHLBI · UNIVERSITY OF FLORIDA · PI Terence E Ryan · 2020 to 2026
$3.6M
The role of fatty fibrosis in chronic limb threatening ischemia pathobiologyR01HL171050 · NHLBI · UNIVERSITY OF FLORIDA · PI Daniel Kopinke, Terence E Ryan · 2024 to 2026
$2.0M
American Heart Association (AHA) 24PRE1191760HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01-HL149704HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01-HL171050NHLBI NIH HHS R01 HL149704NHLBI NIH HHS R01 HL171050
6 · The paper itself

Abstract

Peripheral artery disease (PAD) impairs limb perfusion, walking ability, and increases the risk of amputation. Although current therapies reduce cardiovascular events, few interventions improve skeletal muscle function in PAD. Nicotinamide adenine dinucleotide (NAD

Indexed as

Enzyme InhibitorsIschemiaMuscle, SkeletalNicotinamide N-MethyltransferasePeripheral Arterial DiseaseAgedAnimalsHindlimbHumansMaleMiceMice, Inbred BALB CMice, Inbred C57BLMiddle AgedEnzyme InhibitorsNicotinamide N-MethyltransferaseNNMT protein, humanischemiametabolismskeletal musclevascular disease

Identifiers

PMID41108586
PMCPMC12535215

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.