ArticleProtein science : a publication of the Protein Society2025
A kinetic gatekeeper: TCR-pMHC dissociation dynamics determine T cell activation efficacy.
Article in Protein science : a publication of the Protein Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Mapping the TCR landscape: computational tools empowering translational immunology and therapy design.Journal for immunotherapy of cancer · 2026Review
- Evaluating the effects of CD8/CD4 on T cell function in terms of TCR-pMHC-coreceptor catch and slip bonds.Frontiers in immunology · 2026Article
- Evaluating the effects of CD8/CD4 on T cell function in terms of TCR-pMHC-coreceptor catch and slip bonds.bioRxiv : the preprint server for biology · 2025Article
- A kinetic gatekeeper: TCR-pMHC dissociation dynamics determine T cell activation efficacy.Protein science : a publication of the Protein Society · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
T-cell receptor (TCR) engineering is central to modern immunotherapy, but predicting T-cell functional potency remains challenging, as conventional binding affinity often poorly correlates with cellular responses. Here, we demonstrate that the kinetic properties of the TCR-pMHC dissociation-profiled via steered molecular dynamics (SMD)-serve as a robust predictor of T-cell activation. While affinity-based prediction falls short, peak rupture force and total unbinding work resolve iso-affinity TCRs and correctly rank ligands across the functional spectrum, from antagonist to super-agonist. Notably, we uncover a stage-specific signaling signature: a near-perfect linear correlation between these mechanical metrics and intermediate signaling, which transitions to a strong exponential correlation with final cellular potency (EC
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Registered trials
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