Trial reportClinical and experimental dental research2025
Effectiveness of Cleaning Methods for Resilient Denture Liners: A Three-Period Randomized Crossover Trial.
Trial report in Clinical and experimental dental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effectiveness of Cleaning Methods for Resilient Denture Liners: A Three-Period Randomized Crossover Trial.Clinical and experimental dental research · 2025Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveSeveral studies have demonstrated that insufficient denture hygiene constitutes a significant risk factor for aspiration pneumonia. While various cleaning protocols have been proposed for conventional hard denture base materials, there remains a notable paucity of research specifically addressing effective cleaning strategies for resilient denture liners (RDLs). This study aimed to evaluate the efficacy of three denture cleaning methods-mechanical, chemical, and dual (combined mechanical and chemical)-for removing microbial biofilms from different denture-liner materials using a randomized crossover clinical trial. MATERIALS AND
methodsThis three-period randomized crossover clinical trial included edentulous patients wearing maxillary complete dentures embedded with specimens of a hard-resin liner and silicone-based and acrylic-based RDLs. All liners were fabricated directly in the patient's mouth. Participants performed the three cleaning interventions for 2 weeks each. Swabs from the relined denture surfaces were cultured in phosphate-buffered saline, and the colony-forming units (CFUs) were counted. The influence of each cleaning method on the CFU count was determined.
resultsThe dual-cleaning method demonstrated a significant reduction in CFU count compared to mechanical cleaning, but only for the acrylic-based RDL. No significant differences were observed between the cleaning methods for the silicone-based RDL and hard-resin liner. The CFU count was the highest for silicone-based RDLs, followed by that for acrylic-based RDLs, and hard-resin liners.
conclusionThe dual method comprising mechanical and chemical cleaning was the most effective cleaning strategy for relined dentures, although the advantage was limited to acrylic-based RDL.
trial registrationThis study was registered in the UMIN Clinical Trials Registry (UMIN000056738).
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Registered trials
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