Evidence map›Paper›PMID 41108506›Full record

SynthesisAdvances in therapy2025

Fetal Surgery for Congenital Heart Diseases: A Systematic Review and Single-Arm Meta-analysis.

Larissa Keren de Azevedo Teixeira, Henrique Provinciatto, Gustavo Yano Callado, Caroline de Oliveira Nieblas, Roberta Granese, Edward Araujo Júnior

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Advances in therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Larissa Keren de Azevedo TeixeiraDiscipline of Woman Health, Municipal University of São Caetano do Sul (USCS), São Caetano do Sul, SP, Brazil.ORCID http://orcid.org/0009-0004-7617-7192
Henrique ProvinciattoDepartment of Obstetrics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil.ORCID http://orcid.org/0009-0007-6376-0305
Gustavo Yano CalladoDepartment of Woman Health, Albert Einstein Israelite College of Health Sciences, Albert Einstein Israelite Hospital, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0001-6694-6569
Caroline de Oliveira NieblasDiscipline of Woman Health, Municipal University of São Caetano do Sul (USCS), São Caetano do Sul, SP, Brazil.ORCID http://orcid.org/0000-0002-8639-5677
Roberta GraneseDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, "G. Martino" University Hospital, 98100, Messina, Italy. robertagr74@gmail.com.ORCID http://orcid.org/0000-0003-0318-9390
Edward Araujo JúniorDiscipline of Woman Health, Municipal University of São Caetano do Sul (USCS), São Caetano do Sul, SP, Brazil.ORCID http://orcid.org/0000-0002-6145-2532

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCongenital heart diseases (CHD) are the most common congenital anomalies, and fetal cardiac interventions (FCI) have been developed to improve perinatal outcomes. We aimed to conduct a systematic review and meta-analysis of observational studies to evaluate the effects of FCI on CHD.

methodsWe searched PubMed/Medline, Embase, and the Cochrane Central Register of Controlled Trials from inception to April 2025 without language restrictions. References of included studies and prior reviews were also screened. The protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO; ID CRD42024599628). Eligible studies included observational cohorts evaluating intrauterine procedures for CHD. Data were synthesized using random effects models in RStudio (version 4.2.2), and study quality was assessed with the Newcastle-Ottawa Quality Assessment Form for Cohort Studies (NOS).

resultsTwelve studies including 485 fetuses with CHD were analyzed. The pooled overall survival rate after fetal cardiac intervention was 57.4% (95% confidence interval [CI] 39.8-73.3), with survival ranging from 20.0% to 90.2% across studies. The pooled perinatal mortality rate was 31.5% (95% CI 21.0-44.2), with estimates ranging from 9.8% to 66.7%. Substantial heterogeneity was observed for both outcomes (I

conclusionFCI for CHD are associated with moderate overall survival but substantial perinatal mortality. Standardized protocols, refined patient selection, and multicenter collaboration are needed to improve outcomes and guide clinical decision-making.

Indexed as

Cardiac Surgical ProceduresFetal TherapiesHeart Defects, CongenitalFemaleHumansInfant, NewbornObservational Studies as TopicPregnancyCongenital heart diseaseFetal surgeryIntrauterine interventionPerinatal outcomes

Identifiers

PMID41108506
PMCPMC12618333

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.