Evidence map›Paper›PMID 41108502›Full record

ArticleJournal of endocrinological investigation2026

Relationship between serologically abnormal lipid metabolism and dysthyroid optic neuropathy in patients with thyroid-associated ophthalmopathy.

Haitao Zhang, Beibei Wei, Peng Zhang, Xinjie Duan, Xiaolong Liang, Lu Chen, Jiang Zhou, Wen Chen, Xiaoquan Xu, Hao Hu and 1 more

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Article in Journal of endocrinological investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

11 authors.

Haitao Zhang *Department of Endocrinology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Rd, Gulou district, Nanjing, P.R. China.
Beibei Wei *Department of Endocrinology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Rd, Gulou district, Nanjing, P.R. China.
Peng Zhang *Department of Ophthalmology, The Friendship Hospital of Ili Kazakh Autonomous Prefecture Ili & Jiangsu Joint Institute of Health, Ili, China.
Xinjie DuanDepartment of Endocrinology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Rd, Gulou district, Nanjing, P.R. China.
Xiaolong LiangDepartment of Endocrinology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Rd, Gulou district, Nanjing, P.R. China.
Lu ChenDepartment of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Rd, Gulou district, Nanjing, P.R. China.
Jiang ZhouDepartment of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Rd, Gulou district, Nanjing, P.R. China.
Wen ChenDepartment of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Rd, Gulou district, Nanjing, P.R. China.
Xiaoquan XuDepartment of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Rd, Gulou district, Nanjing, P.R. China.
Hao HuDepartment of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Rd, Gulou district, Nanjing, P.R. China. haohu_njmu@163.com.ORCID http://orcid.org/0000-0002-7983-7377
Huanhuan ChenDepartment of Endocrinology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Rd, Gulou district, Nanjing, P.R. China. drchenhuanhuan@njmu.edu.cn.ORCID http://orcid.org/0000-0003-0201-2059

Funding

Jiangsu Province Hospital (the First Affiliated Hospital with Nanjing Medical University) Clinical Capacity Enhancement Project JSPH-MB-2023-3Jiangsu Provincial Medical Key Discipline (Laboratory) ZDXK202202Medical Research Project of Jiangsu Provincial Health Commission MQ2024050Research Foundation of Yili Institute of Clinical Medicine yl2021ms03"Thyroid Research Program of Young and Middle-aged Physicians" from China Health Promotion Foundation 2019 (PB19)
6 · The paper itself

Abstract

purposeTo investigate the relationship between serologically abnormal lipid metabolism parameters and the onset of dysthyroid optic neuropathy (DON) in patients with thyroid-associated ophthalmopathy (TAO).

methodsA total of 183 patients clinically diagnosed with TAO in the Department of Endocrinology of our hospital from February 2019 to September 2023 were retrospectively enrolled, comprising 34 in the DON group and 149 in the non-DON group. We collected serological lipid metabolism parameters, thyroid function, fasting blood glucose, and other clinical parameters and compared these between the two groups. Multivariable logistic regression analysis was exploited to identify the risk factors associated with the occurrence of DON in patients with TAO.

resultsPatients in the DON group exhibited higher age (P < 0.001) and a greater proportion of men (P = 0.028) than those in the non-DON group. Serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and fasting blood glucose levels were elevated in patients with DON (P = 0.004, P = 0.068, and P = 0.026, respectively). Additionally, the proportions of high serum TC (35.3% vs. 15.4%, P = 0.008) and high serum LDL-C (26.5% vs. 11.4%, P = 0.023) were significantly higher in the DON group than in the non-DON group. Multivariable logistic regression analysis indicated that age and serum TC were independently associated with the onset of DON in patients with TAO (odds ratios = 1.069 and 2.120, respectively; both P < 0.05).

conclusionHypercholesterolemia might be associated with the development of DON, suggesting that high serum TC be strictly managed to reduce the risk of DON in patients with TAO.

Indexed as

Graves OphthalmopathyLipid MetabolismOptic Nerve DiseasesAdultBlood GlucoseFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesRisk FactorsBlood GlucoseDysthyroid optic neuropathyRisk factorSerologically abnormal lipid metabolismThyroid-associated ophthalmopathyTotal cholesterol

Identifiers

PMID41108502

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.