Evidence map›Paper›PMID 41108475›Full record

ArticleBiological trace element research2026

Fluoride Induces Spermatogonial Apoptosis via IP3R-MCU-Mediated Mitochondrial Calcium Overload.

Rong Wang, Han Wang, Wenjing Gong, Xiaoqian Chen, Mengli Zheng, Ya Cui, Chunmei Liang, Jiayue Hu, Yuanhua Chen, Yanli Ji

Abstract read
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In one paragraph

Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rong Wang *Department of Health Inspection and Quarantine, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Han Wang *Department of Health Inspection and Quarantine, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Wenjing Gong *Department of Health Inspection and Quarantine, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Xiaoqian ChenDepartment of Health Inspection and Quarantine, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Mengli ZhengDepartment of Health Inspection and Quarantine, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Ya CuiDepartment of Health Inspection and Quarantine, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Chunmei LiangDepartment of Health Inspection and Quarantine, School of Public Health, Anhui Medical University, Hefei, Anhui, China. liang_chun_mei@126.com.
Jiayue HuDepartment of Health Inspection and Quarantine, School of Public Health, Anhui Medical University, Hefei, Anhui, China. hujiayue@ahmu.edu.cn.
Yuanhua ChenSchool of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China. yuanhuach@126.com.
Yanli JiDepartment of Health Inspection and Quarantine, School of Public Health, Anhui Medical University, Hefei, Anhui, China. ylji@ahmu.edu.cn.

Funding

Postgraduate Innovation Research and Practice Program of Anhui Medical University YJS20240053the Natural Science Research Project for Anhui Universities 2024AH050697
6 · The paper itself

Abstract

Excessive fluoride exposure is associated with male reproductive dysfunction, but the underlying mechanisms remain poorly understood. This study investigated the role of Inositol 1,4,5-trisphosphate receptor (IP3R)-mitochondrial calcium uniporter (MCU)-mediated mitochondrial calcium (Ca

Indexed as

ApoptosisCalciumCalcium ChannelsFluoridesInositol 1,4,5-Trisphosphate ReceptorsMitochondriaSpermatogoniaAnimalsMaleMembrane Potential, MitochondrialMiceOxidative StressCalciumCalcium ChannelsFluoridesInositol 1,4,5-Trisphosphate Receptorsmitochondrial calcium uniporterApoptosisFluorideIP3R-MCU pathwayMitochondrial calcium overloadSpermatogonia

Identifiers

PMID41108475

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.