Evidence map›Paper›PMID 41108447›Full record

ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2026

Helicobacter pylori-naïve status is associated with poor prognosis and aggressive pathological features in undifferentiated-type gastric cancer: a multi-center retrospective cohort study.

Yuxuan Ren, Kefang Sun, Hanjin Yang, Lei Xu, Channi Wu, Yide Zhou, Ye Chen, Chaohui Yu, Lan Li

Abstract readClinical StudyMulticenter Study
PubMed Publisher
In one paragraph

Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuxuan RenDepartment of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Kefang SunInternal Medicine Residency Program, Rochester General Hospital, Rochester, NY, 14621, USA.
Hanjin YangDepartment of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Lei XuDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, China.
Channi WuDepartment of Gastroenterology, Zhejiang Xiaoshan Hospital, Hangzhou, 311200, China.
Yide ZhouDepartment of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Ye ChenDepartment of Mathematics and Statistics, Northern Arizona University, Flagstaff, AZ, 86011, USA.
Chaohui YuDepartment of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Lan LiDepartment of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. nalil@zju.edu.cn.ORCID 0000-0001-8401-4001

Funding

National Natural Science Foundation of China 81970498National Natural Science Foundation of China 82570662Natural Science Foundation of Zhejiang Province LZ22H030002
6 · The paper itself

Abstract

backgroundUndifferentiated-type gastric cancer (UGC) is more pathologically aggressive and progresses faster than differentiated-type gastric cancer (DGC). However, the impact of Helicobacter pylori (Hp) status on survival outcomes and clinicopathological features of UGC remains unclear.

methodsThis multi-center retrospective study analyzed 571 patients pathologically confirmed UGC from January 2011 to December 2021. Clinical and histopathological features and survival outcomes were compared between Hp-naïve undifferentiated-type gastric cancer (HpNUGC) and Hp-infected undifferentiated-type gastric cancer (HpIUGC).

results571 patients including 283 HpNUGC (49.6%) and 288 HpIUGC (50.4%) were enrolled in survival analysis. The 5-year event-free survival (EFS) and 5-year overall survival (OS) rates were significantly lower in the HpNUGC group compared to the HpIUGC group (EFS: 46.3% vs. 64.3%, P < 0.001; OS: 54.3% vs. 67.7%, P < 0.001). Hp-naïve status was associated with a 57% higher risk of disease progression, recurrence, or death, collectively termed "events" in this study (HR 1.57; 95% CI 1.20-2.04), and a 50% higher risk of all-cause mortality (HR 1.50, 95% CI 1.12-2.00). The HpNUGC lesions demonstrated larger tumor diameters (P < 0.001), deeper invasion depths (P < 0.001), more frequent lymphatic metastasis (P = 0.003), more advanced disease stages (P = 0.002), and higher rates of positive incision margins (P = 0.049).

conclusionHpNUGC is associated with worse survival outcomes and exhibits more malignant pathological features compared to HpIUGC. Future prospective studies are needed to clarify the relationship between Hp status and the development and progression of UGC.

Indexed as

Helicobacter InfectionsHelicobacter pyloriStomach NeoplasmsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesSurvival RateEvent-free survivalHelicobacter pyloriOverall survivalPathological featuresUndifferentiated-type gastric cancer

Identifiers

PMID41108447

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