ArticleAIDS and behavior2026
Discontinuation of Pre-exposure Prophylaxis in Men Who Have Sex with Men in Taiwan: A Prospective Study of Event-Driven Regimens.
Article in AIDS and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Event-driven dosing is the preferred option for oral pre-exposure prophylaxis (PrEP) among men who have sex with men (MSM) in Taiwan. A key challenge to PrEP scale-up is discontinuation at clinical follow-up, with event-driven users potentially facing higher risk of discontinuation and missing routine health checks. This study examined PrEP discontinuation and associated factors in a sample with a high proportion of event-driven users. Adult MSM receiving PrEP at a medical center in southern Taiwan were enrolled in 2018-2023. PrEP discontinuation, defined as no clinical visit for over 6 months, was analysed using Kaplan-Meier and log-rank tests comparing dosing regimen groups. Cox regression models with time-varying covariates were performed to identify associations between PrEP user characteristics and discontinuation. A total of 301 MSM with a median age of 28 years were analysed. Over 1379 person-times of follow-up, 57.1% discontinued PrEP within one year, with median time of 210 days. Cox regression models incorporating time-varying covariates for PrEP regimen and behavioral factors indicated that event-driven PrEP use (aHR = 1.87, 95% CI 1.01-3.49), higher monthly salary (aHR = 1.87, 95% CI 1.18-2.95), and lack of government-subsidized PrEP (aHR = 2.14, 95% CI 1.38-3.32) were associated with higher risk of PrEP discontinuation at clinical follow-up. Event-driven users show higher discontinuation rates at clinical follow-up in Taiwan. Differentiated service delivery better-tailoring resources to PrEP users' demand should be developed such as flexible visit schedules, telemedicine consultations, and community-based PrEP refill programs as many MSM prefer event-driven regimens.
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