ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Retinal microstructual and microvascular changes in mucopolysaccharidoses.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyse ocular manifestations of MPS in the posterior segment of the eye, in particular retinal and optic disc pathologies, compared to healthy controls.
methodsThis prospective study analyzed structural and functional posterior eye changes in 29 MPS patients (58 eyes) compared to 29 healthy, age- and gender-matched controls. Examinations included visual acuity testing, orthoptic status, intraocular pressure (IOP) measurement, visual field testing, slit-lamp examination and fundus examination, Spectral-Domain Optical Coherence Tomography (SD-OCT), OCT-Angiography (OCT-A) and High Magnification Module
resultsLogMAR visual acuity (p < 0.001) and IOP (p < 0.001) were significantly worse/higher in MPS patients. Visual field defects showed a concentric restriction pattern, resembling to pigmentary retinopathy. Fundus examination of 56 eyes revealed optic disc atrophy in two eyes (all MPS II), atrophic macula in two eyes (both MPS II) and pigmentary retinopathy in twelve eyes (6 MPS II, 6 MPS IV). Total retinal thickness was significantly reduced in the parafoveal (p < 0.001) and perifoveal (p < 0.001) macula area in MPS, especially in MPS II patients. Peripapillary retinal nerve fiber layer thickness correlated positively with IOP (p = 0,015) in the MPS group. OCT-A findings revealed reduced capillary density of the parafoveal and perifoveal retina in 8/22 eyes in the MPS group (2 MPS I, 4 MPS II, 2 MPS IV). Rarefaction of the photoreceptor mosaic was observed in some MPS patients on HMM imaging.
conclusionMPS patients exhibit impaired visual acuity and visual fields, higher IOP, and mircostructural and microvascular alterations of the optic disc and retina compared to healthy subjects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.