ReviewGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2025
Nonadherence to anti-VEGF intravitreal injections in patients with diabetic macular edema : The names of the authors.
Review in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Lost to follow-up while undergoing intravitreal injection therapy: barriers to adherence in a real-world setting.International journal of retina and vitreous · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Diabetic macular edema (DME) is a principal cause of impaired vision in individuals with diabetes. The effectiveness of treatment using intravitreal injection (IVI) of anti-vascular endothelial growth factor (anti-VEGF) has been established in clinical trials, and it has become the treatment of choice for the majority of DME patients. However, real-world treatment outcomes for patients with DME have consistently lagged behind those reported in clinical trials. Nonadherence to IVI treatment and loss to follow-up (LTFU) limit the results of clinical treatment for patients with DME in real-world conditions.Herein, we report results from different real-world studies and analyse high levels of nonadherence to anti-VEGF treatment in patients with DME. IVI adherence may involve a variety of patient-related, condition-related, therapy-related, and COVID-19-related factors. Notably, although the overall adherence rate to IVI declined during the COVID-19 pandemic, targeted interventions addressing treatment barriers significantly improved DME patient adherence. In this review, we highlight changes in IVI practices that were implemented to reduce nonadherence in patients with DME during the pandemic, along with other emerging strategies, including assessments of the risk of visual impairment and prioritisation of treatment; distinguishing among types of appointments; modifications of anti-VEGF injection protocols; diversification of medical services, telemedicine, and artificial intelligence (AI); and improvements in patient education.Our analysis identified multifaceted factors associated with nonadherence to IVI among DME patients and proposed corresponding intervention strategies. Future investigations should focus on developing clinically feasible adherence assessment tools and standardised metrics to facilitate individualised therapeutic decision-making. We advocate for the systematic integration of adherence monitoring into standardized clinical workflows as a fundamental component of IVI management protocols. This evidence-based paradigm holds significant promise in addressing the growing practical challenges in contemporary DME management.
Indexed as
Identifiers
41108384What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.