Evidence map›Paper›PMID 41108276›Full record

ArticleJournal of medicinal chemistry2025

Increasing the Chemical Space of L-SIGN Specific Glycomimetics.

Gianluca Cavazzoli, Clara Delaunay, Sara Pollastri, Andrea Panzeri, Sara Sattin, Michel Thépaut, Laura Belvisi, Franck Fieschi, Anna Bernardi

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Synthetic Ligands of Myeloid C-Type Lectin Receptors.Chembiochem : a European journal of chemical biology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gianluca CavazzoliDipartimento di Chimica, Università degli Studi di Milano, via Golgi 19, Milano 20133, Italy.ORCID 0009-0001-2149-0200
Clara DelaunayInstitut de Biologie Structurale, Univ. Grenoble Alpes, CNRS, CEA, Grenoble 38000, France.
Sara PollastriDipartimento di Chimica, Università degli Studi di Milano, via Golgi 19, Milano 20133, Italy.ORCID 0000-0002-8118-7238
Andrea PanzeriDipartimento di Chimica, Università degli Studi di Milano, via Golgi 19, Milano 20133, Italy.ORCID 0009-0006-8418-2017
Sara SattinDipartimento di Chimica, Università degli Studi di Milano, via Golgi 19, Milano 20133, Italy.ORCID 0000-0002-5558-3915
Michel ThépautInstitut de Biologie Structurale, Univ. Grenoble Alpes, CNRS, CEA, Grenoble 38000, France.
Laura BelvisiDipartimento di Chimica, Università degli Studi di Milano, via Golgi 19, Milano 20133, Italy.ORCID 0000-0002-3593-2970
Franck FieschiInstitut de Biologie Structurale, Univ. Grenoble Alpes, CNRS, CEA, Grenoble 38000, France.ORCID 0000-0003-1194-8107
Anna BernardiDipartimento di Chimica, Università degli Studi di Milano, via Golgi 19, Milano 20133, Italy.ORCID 0000-0002-1258-2007

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selective ligands for the C-type lectin receptor L-SIGN offer promising avenues in antiviral therapies and for tissue-specific delivery. We recently reported that a guanidine-bearing modified mannose glycomimetic, called

Indexed as

Antiviral AgentsCell Adhesion MoleculesLectins, C-TypeMannoseReceptors, Cell SurfaceCrystallography, X-RayDC-Specific ICAM-3 Grabbing NonintegrinHumansLigandsModels, MolecularProtein BindingSARS-CoV-2Spike Glycoprotein, CoronavirusAntiviral AgentsCell Adhesion MoleculesDC-Specific ICAM-3 Grabbing NonintegrinLectins, C-TypeLigandsMannoseReceptors, Cell SurfaceSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2

Identifiers

PMID41108276
PMCPMC12621191

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.