Evidence map›Paper›PMID 41108128›Full record

ArticleJournal of dental research2026

Effects of Circadian Misalignment on Young and Aging Salivary Glands.

H Mortazavi, R Said, G S Katselis, P Chumala, G Pannone, S Papagerakis, P Papagerakis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

H MortazaviDepartment of Anatomy, Physiology, and Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
R SaidARThrite Research Center (Arthrite Research Treatment), Centre Hospitalier Universitaire de Québec Research Centre, Université Laval, Québec, QC, Canada.ORCID 0000-0003-4947-4170
G S KatselisDepartment of Medicine, Canadian Centre for Rural and Agricultural Health, Mass Spectrometry Lab for Omics Research, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
P ChumalaCanadian Centre for Rural and Agricultural Health, Mass Spectrometry Lab for Omics Research, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
G PannoneDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
S PapagerakisARThrite Research Center (Arthrite Research Treatment), Centre Hospitalier Universitaire de Québec Research Centre, Université Laval, Québec, QC, Canada.
P PapagerakisDepartment of Anatomy, Physiology, and Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several empirical observations strongly suggest that salivary function is regulated by the circadian clock. Salivary volume, electrolytes levels, and saliva protein composition all show 24-h cycle fluctuations. The exact effects of circadian disruption on salivary gland (SG) physiology and its potential role in salivary pathologies have not been elucidated. Here, we examined the effects of circadian disruption on SG structure, functional gene and protein expression, and immune status using several circadian knockout (KO) mice models where we targeted the following canonical clock genes: brain and muscle ARNT-like 1 protein (

Indexed as

AgingCircadian RhythmSalivary GlandsAnimalsARNTL Transcription FactorsCircadian ClocksCryptochromesFemaleMiceMice, Inbred C57BLMice, KnockoutPeriod Circadian ProteinsSalivaARNTL Transcription FactorsBmal1 protein, mouseCryptochromesPeriod Circadian Proteinsautoimmunitycircadian rhythmscytokinessalivasalivary physiologySjögren’s disease

Identifiers

PMID41108128
PMCPMC13068144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.