Evidence map›Paper›PMID 41108126›Full record

ArticleCell transplantation

Adipose-derived stem cells inhibit dendritic cell migration by secreting tumor necrosis factor-α-stimulated gene 6 to improve the allogeneic skin transplantation survival rate in mice.

Julong Hu, Wenxu Peng, Yeltai Nurzat, Qi Zhang, Zaihuan Lin, Jianlei Xie, Meiqian Xu, Hang Ji, Gang Liang, Zhihua Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Julong HuState Key Laboratory of Respiratory Disease, Laboratory of ENT-HNS Disease, Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID 0000-0001-6103-8801
Wenxu PengState Key Laboratory of Respiratory Disease, Laboratory of ENT-HNS Disease, Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID 0009-0005-8791-5485
Yeltai NurzatState Key Laboratory of Respiratory Disease, Laboratory of ENT-HNS Disease, Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID 0000-0003-3188-6505
Qi ZhangState Key Laboratory of Respiratory Disease, Laboratory of ENT-HNS Disease, Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zaihuan LinState Key Laboratory of Respiratory Disease, Laboratory of ENT-HNS Disease, Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Jianlei XieState Key Laboratory of Respiratory Disease, Laboratory of ENT-HNS Disease, Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID 0000-0002-7357-4676
Meiqian XuState Key Laboratory of Respiratory Disease, Laboratory of ENT-HNS Disease, Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Hang JiDepartment of Plastic and Reconstructive Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Gang LiangDepartment of Plastic and Reconstructive Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhihua ZhangDepartment of Plastic and Reconstructive Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Wenjing LiaoState Key Laboratory of Respiratory Disease, Laboratory of ENT-HNS Disease, Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiaowen ZhangState Key Laboratory of Respiratory Disease, Laboratory of ENT-HNS Disease, Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID 0000-0001-5255-8610

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allogeneic skin transplantation faces significant immunological challenges due to immune rejection, primarily mediated by dendritic cells (DCs). Adipose-derived stem cells (ADSCs) possess immunomodulatory effects; however, the underlying molecular mechanisms in regulating DC function remain unclear. This study aimed to investigate the regulatory effects of ADSCs and tumor necrosis factor-α-stimulated gene 6 (TSG-6) secreted by ADSCs on DC in the murine allogeneic skin transplantation. Following transplantation, recipients received ADSCs, TSG-6 knockdown ADSCs (ADSCs-shTSG-6), or control treatments. Immune cell infiltration and cytokine expression were analyzed by flow cytometry and immunohistochemistry. Transwell assays were used to assess the effect of TSG-6 on DCs migration. TSG-6-related gene expression profiles were explored using transcriptomic analysis and validated by RT-qPCR. ADSC treatment significantly reduced the migration of DCs to the recipient than the ADSCs-shTSG-6 treatment, while reducing the levels of macrophages, lymphocytes, and pro-inflammatory cytokines. ADSC-derived TSG-6 inhibited DCs migration, an effect diminished upon TSG-6 knockdown and restored by TSG-6 supplementation. Transcriptomic analysis identified a panel of immune-related genes (ADM, GHRH, SELENBP1, NDRG1) regulated by TSG-6. These findings indicate that ADSCs enhance graft tolerance by inhibiting DCs migration via TSG-6 secretion, highlighting TSG-6 as a promising therapeutic target for preventing transplant rejection.

Indexed as

Adipose TissueCell Adhesion MoleculesCell MovementDendritic CellsSkin TransplantationStem CellsAnimalsMiceMice, Inbred BALB CMice, Inbred C57BLTransplantation, HomologousCell Adhesion MoleculesTnfaip6 protein, mouseadipose-derived stem cellsallogeneic skin graftdendritic cellsimmune modulationtumor necrosis factor-α-stimulated gene 6

Identifiers

PMID41108126
PMCPMC12547123

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.