Evidence map›Paper›PMID 41108067›Full record

ArticleCell proliferation2026

Hcfc1 and Ogt Mediate Zebrafish CNS Regeneration Through Hippo/Yap Signalling.

Priyanka P Srivastava, Sidharth Bhasin, Poonam Sharma, Omkar Mahadeo Desai, Kshitiz Yadav, Ayushma, Rohan Chakraborty, Suhel Parvez, Rajesh Ramachandran, Shilpi Minocha

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In one paragraph

Article in Cell proliferation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Priyanka P SrivastavaKusuma School of Biological Sciences, Indian Institute of Technology Delhi (IITD), New Delhi, India.ORCID https://orcid.org/0009-0005-8437-0694
Sidharth BhasinKusuma School of Biological Sciences, Indian Institute of Technology Delhi (IITD), New Delhi, India.
Poonam SharmaDepartment of Biological Sciences, Indian Institute of Science Education and Research, Mohali, India.
Omkar Mahadeo DesaiDepartment of Biological Sciences, Indian Institute of Science Education and Research, Mohali, India.
Kshitiz YadavDepartment of Biological Sciences, Indian Institute of Science Education and Research, Mohali, India.ORCID https://orcid.org/0009-0000-9620-2018
AyushmaKusuma School of Biological Sciences, Indian Institute of Technology Delhi (IITD), New Delhi, India.
Rohan ChakrabortyDepartment of Medical Elementology and Toxicology, Jamia Hamdard University, New Delhi, India.
Suhel ParvezDepartment of Medical Elementology and Toxicology, Jamia Hamdard University, New Delhi, India.ORCID https://orcid.org/0000-0002-6318-6506
Rajesh RamachandranDepartment of Biological Sciences, Indian Institute of Science Education and Research, Mohali, India.
Shilpi MinochaKusuma School of Biological Sciences, Indian Institute of Technology Delhi (IITD), New Delhi, India.

Funding

Anusandhan National Research Foundation SRG/2021/000341IFCPAR/CEFIPRA (Indo-French Centre for Promotion of Advanced Research/Centre Franco-Indien pour la Promotion de la Recherche Avancée) 6503-JNPDF from DST (Department of Science and Technology) PDF/2019/001148Postdoctoral fellowship support from DBT (Department of Biotechnology) DBT-RA/2023/July/N/4351Ramalingaswami re-entry fellowship from the Department of Biotechnology BT/RLF/Re-entry/70/2017research funding from DBT India BT/PR36570/BRB/10/1976/2021research funding from DBT India BT/PR53768/BMS/85/157/2024
6 · The paper itself

Abstract

Regeneration of the central nervous system (CNS) is a complex and tightly regulated process, yet the precise molecular players and transcriptional regulators involved remain incompletely understood. Here, we identify Host Cell Factor-1 (Hcfc1), a transcriptional co-regulator, and O-GlcNAc transferase (Ogt), which cleaves and O-GlcNAcylates HCF-1, as crucial regulators of zebrafish brain and retinal regeneration. We uncover their interplay with the Hippo/Yap signalling pathway, a well-known regulator of tissue growth and repair. Knockdown of hcfc1a/b or Ogt activity inhibition disrupts regeneration and reduces Yap levels, while Yap inhibition alone also impairs regeneration. Strikingly, overexpression of constitutively active Yap5SA rescues proliferation defects caused by Hcfc1 depletion and Ogt inhibition in retinal regeneration. Further, yap1 knockdown reduces hcfc1a/b levels, suggesting potential feedback regulation. These findings reveal a previously unrecognised regulatory axis involving Hcfc1, Ogt, and the Hippo/Yap pathway, which governs CNS regeneration. Targeting this pathway could offer a strategy for enhancing CNS regeneration.

Indexed as

Central Nervous SystemHost Cell Factor C1N-AcetylglucosaminyltransferasesProtein Serine-Threonine KinasesRegenerationZebrafishZebrafish ProteinsAnimalsCell ProliferationHippo Signaling PathwayRetinaSignal TransductionYAP-Signaling ProteinsHost Cell Factor C1N-AcetylglucosaminyltransferasesO-GlcNAc transferaseProtein Serine-Threonine KinasesYAP-Signaling ProteinsYes-associated protein (yap), zebrafishZebrafish ProteinsbrainHcfc1Hippo/Yap signallingOgtregenerationretinazebrafish

Identifiers

PMID41108067
PMCPMC13114781

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.