Evidence map›Paper›PMID 41108062›Full record

ArticleVirulence2025

Eukaryotic translation elongation factor 1 alpha 1 facilitates coxsackievirus B replication through interacting with PABP, viral protein 3 CD and viral RNA.

Shuoxuan Zhao, Yanyan Dong, Yao Wang, Hong Yang, Tian Luan, Yingxia He, Lexun Lin, Yang Chen, Yanru Fei, Guangtian Wang and 4 more

Abstract read
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In one paragraph

Article in Virulence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shuoxuan ZhaoDepartment of Cell Biology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Yanyan DongDepartment of Cell Biology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Yao WangDepartment of Cell Biology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Hong YangDepartment of Cell Biology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Tian LuanDepartment of Cell Biology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Yingxia HeDepartment of Cell Biology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Lexun LinTeaching Center of Pathogen Biology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Yang ChenTeaching Center of Pathogen Biology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Yanru FeiDepartment of Microbiology Biology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Guangtian WangTeaching Center of Pathogen Biology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Yan WangDepartment of Microbiology Biology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Zhaohua ZhongDepartment of Microbiology Biology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Nan QiState Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Wenran ZhaoDepartment of Cell Biology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.ORCID 0000-0003-2495-5138

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral myocarditis, often caused by Coxsackievirus B (CVB), is the leading cause of dilated cardiomyopathy and heart failure. Despite extensive research, the pathogenesis of CVB infection remains incompletely understood. Our previous study found that Anisomycin inhibits CVB replication by promoting the degradation of eukaryotic translation elongation factor 1 alpha 1 (eEF1A1). However, the precise mechanism through which eEF1A1 facilitates the replication of CVB remains to be fully elucidated. Here, we demonstrated that upregulated eEF1A1 is required for CVB3 replication.

Indexed as

Enterovirus B, HumanPeptide Elongation Factor 1RNA, ViralVirus ReplicationAnimalsCoxsackievirus InfectionsHost-Pathogen InteractionsHumansProtein BindingEEF1A1 protein, humanPeptide Elongation Factor 1RNA, Viral5’-untranslated regionCoxsackievirus Beukaryotic translation elongation factor 1 alpha 1nuclear factor kappa BPoly(A)-binding proteinviral myocarditis

Identifiers

PMID41108062
PMCPMC12539751

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.