Evidence map›Paper›PMID 41107988›Full record

ArticleJournal of translational medicine2025

IL-17 + γδT cell: a new target in hyperbaric oxygen treatment reducing spinal cord injury.

Mo Liu, Zhencheng Sun, Fang Liang, Ruizhang Yao, Lu Yang, Ding Nan, Jing Yang, Qingjun Su, Xuehua Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mo LiuDepartment of Hyperbaric Oxygen, Beijing Chao-Yang Hospital Capital Medical University, Beijing, 100020, China.
Zhencheng SunDepartment of Orthopedic Surgery, Qilu Hospital of Shandong University, Qingdao, 266101, China.
Fang LiangDepartment of Hyperbaric Oxygen, Beijing Chao-Yang Hospital Capital Medical University, Beijing, 100020, China.
Ruizhang YaoDepartment of Orthopedic Surgery, Beijing Chao-Yang Hospital Capital Medical University, Beijing, 100020, China.
Lu YangDepartment of Hyperbaric Oxygen, Beijing Chao-Yang Hospital Capital Medical University, Beijing, 100020, China.
Ding NanDepartment of Hyperbaric Oxygen, Beijing Chao-Yang Hospital Capital Medical University, Beijing, 100020, China.
Jing YangDepartment of Hyperbaric Oxygen, Beijing Chao-Yang Hospital Capital Medical University, Beijing, 100020, China.
Qingjun SuDepartment of Orthopedic Surgery, Beijing Chao-Yang Hospital Capital Medical University, Beijing, 100020, China.
Xuehua LiuDepartment of Hyperbaric Oxygen, Beijing Chao-Yang Hospital Capital Medical University, Beijing, 100020, China. liuxuehua_1981@163.com.ORCID 0000-0002-1385-4852

Funding

Beijing Chao-Yang Hospital Multi-disciplinary Team Program CYDXK202208National Natural Science Foundation of China No. 82101964Natural Science Foundation of Beijing Municipality No. 7202055
6 · The paper itself

Abstract

backgroundHyperbaric oxygen (HBO) treatment can attenuate the inflammatory response after spinal cord injury (SCI), but the specific molecular mechanisms are unclear. γδT cells have emerged as key immune regulatory cells. This study aims to analyze the mechanism of HBO treatment reducing SCI mainly from the perspective of γδT cells.

methodsContusion SCI models were established in WT, TCRδ

resultsOur results showed γδT cells, especially IL-17 + γδT cells, were involved in SCI. HBO treatment improved locomotor recovery, reduced the proportion of γδT and IL-17 + γδT cells, and decreased inflammatory cytokines in WT mice after SCI. However, HBO treatment did not affect locomotor recovery or inflammatory cytokines level in TCRδ

conclusionsThese findings indicated that IL-17 + γδT cells may play a key role in HBO treatment alleviating the inflammatory response after SCI. HBO treatment may regulate IL-17 + γδT cells by modulating the pathway of STAT3/RORγt. This study provides the theoretical basis and potential therapeutic target for HBO treatment in SCI.

Indexed as

Hyperbaric OxygenationInterleukin-17Receptors, Antigen, T-Cell, gamma-deltaSpinal Cord InjuriesAnimalsCytokinesInflammationLocomotionMiceMice, Inbred C57BLMice, KnockoutNuclear Receptor Subfamily 1, Group F, Member 3Recovery of FunctionSTAT3 Transcription FactorCytokinesInterleukin-17Nuclear Receptor Subfamily 1, Group F, Member 3Receptors, Antigen, T-Cell, gamma-deltaSTAT3 Transcription FactorHyperbaric oxygenInflammatory cytokinesSpinal cord injuryγδT cell

Identifiers

PMID41107988
PMCPMC12535067

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.