Evidence map›Paper›PMID 41107970›Full record

ArticleParticle and fibre toxicology2025

Short-term association between ambient air pollution and heart rate variability: results from the population-based KORA S4 and FF4 studies.

Yujiao Li, Susanne Breitner-Busch, Wayne E Cascio, Siqi Zhang, Kathrin Wolf, Ina-Maria Rückert-Eheberg, Stefan Kääb, Georg Schmidt, Alexander Strom, Annette Peters and 1 more

Abstract read
In one paragraph

Article in Particle and fibre toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yujiao LiInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. yujiao.li@helmholtz-munich.de.
Susanne Breitner-BuschInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Wayne E CascioUS Environmental Protection Agency, Durham, NC, USA.
Siqi ZhangDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA.
Kathrin WolfInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Ina-Maria Rückert-EhebergInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Stefan KääbGerman Research Center for Cardiovascular Disease (DZHK), Partner site Munich Heart Alliance, Munich, Germany.
Georg SchmidtGerman Research Center for Cardiovascular Disease (DZHK), Partner site Munich Heart Alliance, Munich, Germany.
Alexander StromInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Alexandra SchneiderInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmbient air pollution is a major risk factor for CVDs, and a plausible mechanism is speculated to be alteration of autonomic nervous system (ANS) function. Yet, the short-term effects of air pollution on heart rate variability (HRV), a measure of ANS balance are inconsistent.

objectiveThis study aimed to evaluate the short-term effects of ambient PM

methodsWe analyzed data from 4,032 participants in KORA S4 (1999-2001) and 1,912 in KORA FF4 (2013-2014). Air pollution data were from fixed monitoring stations, and HRV indices were derived from 5-minute ECG recordings. Generalized additive models (GAMs) and generalized additive mixed models (GAMMs) were used to assess associations.

resultsIn S4, each IQR increase in PM

conclusionShort-term exposure to PM

Indexed as

Air PollutantsAir PollutionAutonomic Nervous SystemEnvironmental ExposureHeart RateNitrogen DioxideParticulate MatterAdultAgedFemaleHumansMaleMiddle AgedAir PollutantsNitrogen DioxideParticulate MatterAgingAir pollutionCardiac autonomic functionCardiovascular diseasesHeart rate variability

Identifiers

PMID41107970
PMCPMC12534996

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.