Evidence map›Paper›PMID 41107943›Full record

ReviewLipids in health and disease2025

Role of lipid droplets in pulmonary arterial hypertension: focusing on pulmonary artery smooth muscle cell proliferation.

Baishi Huang, Yu Hao, Zhe Wen, Jie Dong, Shengwei Jin, Hui Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Baishi HuangDepartment of Anesthesia and Critical Care, The Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan Road, Lucheng District, Wenzhou, 325027, Zhejiang, China.
Yu HaoDepartment of Anesthesia and Critical Care, The Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan Road, Lucheng District, Wenzhou, 325027, Zhejiang, China.
Zhe WenDepartment of Anesthesia and Critical Care, The Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan Road, Lucheng District, Wenzhou, 325027, Zhejiang, China.
Jie DongDepartment of Anesthesia and Critical Care, The Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan Road, Lucheng District, Wenzhou, 325027, Zhejiang, China.
Shengwei JinDepartment of Anesthesia and Critical Care, The Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan Road, Lucheng District, Wenzhou, 325027, Zhejiang, China.
Hui LiDepartment of Anesthesia and Critical Care, The Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan Road, Lucheng District, Wenzhou, 325027, Zhejiang, China. lihui0623@wmu.edu.cn.

Funding

Medical Health Science and Technology Project of Zhejiang Provincial Health Commission 2025KY105National Natural Science Foundation of China 82300072Natural Science Foundation of Zhejiang Province LQ23H010003Wenzhou Municipal Science and Technology Bureau Y20240079
6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is a devastating disease complicated by pathological features such as proliferation of pulmonary artery smooth muscle cells (PASMCs), vasoconstriction, increased pulmonary artery pressure, and hypertrophic right heart failure. Among these features, excessive proliferation of PASMCs is the most significant pathological change in this disease. Lipid droplets (LDs) are ubiquitous cellular organelles that serve as energy storage sites. Previous studies have shown that large accumulations of intracellular LDs are observed in proliferating cells (such as stem cells and cancer cells) and that the modulation of LD accumulation can affect cell proliferation. These findings suggest that LDs play important roles in cell proliferation. This review aimed to investigate the role of LDs in PAH by focusing on the proliferation of PASMCs.

Indexed as

Hypertension, PulmonaryLipid DropletsMuscle, Smooth, VascularMyocytes, Smooth MusclePulmonary Arterial HypertensionPulmonary ArteryAnimalsCell ProliferationHumansCell proliferationEpithelial‒mesenchymal transitionHypoxiaLipid dropletsPulmonary arterial hypertension

Identifiers

PMID41107943
PMCPMC12533464

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.