Evidence map›Paper›PMID 41107931›Full record

ArticleJournal of translational medicine2025

Nicotinamide riboside attenuates radiation-induced intestinal injury by suppressing gasdermin E-mediated pyroptosis in intestinal epithelial cells.

Qian Zhou, Le Liu, Xinlong Lin, Binhai Shen, Weifeng Huang, Yin Zhang, Yinmu Li, Yuyi Yang, Hongbin Liu, Wendi Zhang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Berberine AlleviatesInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Qian Zhou *Guangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. zhouqiansunshine@163.com.
Le Liu *Department of Gastroenterology, Shenzhen Hospital, Southern Medical University, Shenzhen, 510086, China.
Xinlong LinGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Binhai ShenGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Weifeng HuangGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yin ZhangGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yinmu LiGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yuyi YangGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Hongbin LiuGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Wendi ZhangGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Xinmei ZhaoGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Weiguang QiaoGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yangyang LiuGuangzhou ZhiYi Biotechnology Co., Ltd, Guangzhou, 510535, China.
Gao TanGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. tgao0316@163.com.
Fachao ZhiGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. zhifc41532@163.com.ORCID 0000-0001-8674-4737

Funding

Guangdong Science and Technology Project No.2017B020209003Guangzhou Science and Technology Plan Project Key Research and Development Plan 2024 Agricultural and Social Development Science and Technology Topic NO.2024B03J1282National Natural Science Foundation of China Project No.81770530, Project No.81970465, Project No.82172729President Foundation of Nanfang Hospital, Southern Medical University No. 2023B043Science and Technology Projects in Guangzhou 2023A04J2282Shenzhen Science and Technology Program No. JCYJ202205303002642; No. RCBS20221008093243060
6 · The paper itself

Abstract

introductionRadiation-induced intestinal injury (IR) is a common complication in patients with colorectal cancer (CRC) after radiotherapy. Currently, the search for effective treatments has become an urgent priority. Nicotinamide riboside (NR), the precursor of vitamin B3 derivative and NAD (+), was enriched in IR after treatment with commensal Bacteroides fragilis, suggesting that NR may perform a protective role. However, the specific role of NR in IR remains unclear. In this study, we investigated the therapeutic effects of NR on IR.

methodsC57BL/6J, Gsdme

resultsNR significantly ameliorated IR in mice, as evidenced by reduced weight loss, shortened small intestinal and colonic length, improved histological associated index, and restored the intestinal flora, which increased the relative abundance of the commensal Muribaculaceae, and decreased the relative abundance of Escherichia_coli. Additionally, NR increased goblet cell density, increased crypt length, promoted Ki-67 and ZO-1 expression, reduced reactive oxygen species (ROS) levels, and maintained mitochondrial morphology in IECs. Mechanistically, NR activated SIRT1 and inhibited gasdermin E (GSDME)-induced pyroptosis. Further investigations using an experimental Gsdme

conclusionOur study demonstrated that NR mitigates IR by inhibiting GSDME-mediated pyroptosis and restoring IECs homeostasis. These findings suggest that NR could serve as a promising therapeutic strategy for IR following radiotherapy.

Indexed as

Epithelial CellsIntestinal MucosaIntestinesNiacinamidePyroptosisRadiation InjuriesAnimalsCell LineMaleMiceMice, Inbred C57BLOrganoidsPyridinium CompoundsSirtuin 1Niacinamidenicotinamide-beta-ribosidePyridinium CompoundsSirtuin 1Gasdermin EIntestinal epithelial cellsNicotinamide ribosidePyroptosisRadiation-induced intestinal injury

Identifiers

PMID41107931
PMCPMC12535104

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.