ArticleJournal of health, population, and nutrition2025
Prevalence, radio-clinical patterns and factors associated with pulmonary tuberculosis among children with severe acute malnutrition: a cross-sectional study in Uganda.
Article in Journal of health, population, and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Tuberculosis prevalence among children with severe acute malnutrition: a systematic review and meta-analysis.medRxiv : the preprint server for health sciences · 2026Article
- The Spectrum of Pathogens Associated with Infections in African Children with Severe Acute Malnutrition: A Scoping Review.Tropical medicine and infectious disease · 2024Article
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10 authors.
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Abstract
backgroundAlthough treatable, pulmonary tuberculosis (PTB) has a significant morbidity and mortality. Children with malnutrition are immune compromised, which increases the morbidity and mortality of PTB. Literature from other countries has shown that the occurrence of malnutrition is significantly associated with tuberculosis, but there is a paucity of data about this subject in Uganda, yet throughout the past 15 years, Uganda's rate of malnutrition reduction has been quite very slow.
methodsThis was a cross-sectional study among children aged 6-59 months with SAM at JRRH. History was taken and physical examination done. Gene Xpert was done for all participants, Lipoarabinomannan Antigen Assay for TB (TB-LAM) done for HIV positive children with CD4 below 200 and Chest X-ray for children who presented with cough and difficulty in breathing. Both the investigations and clinical findings were used to make a diagnosis of PTB. Using binary logistic regression in SPSS, the factors associated with Tuberculosis were determined. P value < 0.05 was considered significant.
resultsOf the 137 children enrolled with SAM, the majority were in the age groups of 6-11 and 12-23 months. Non-edematous malnutrition was the commonest 73(53.3%). Thirty-two children were diagnosed with TB with a prevalence of 23.4%. Of the 32 diagnosed with Tuberculosis, only 5 had a positive gene expert test, 2 had a positive urine TB LAM and the remaining 25 were diagnosed using clinical criteria. The commonest symptoms among children diagnosed with TB were cough seen in 25/32 (78.1%) and fever in 24/32 (75%). The most common radiological findings comprised adenopathy (64.3%) and consolidations (49.7%). Coming from rural areas (aOR = 1.205, 95%CI = 1.067-1.360, P = 0.003), being HIV positive (aOR = 1.619, CI = 1.114-2.354, P = 0.012), thrombocytopenia (aOR = 1.407, CI = 1.069-1.853, P = 0.015) and thrombocytosis (aOR = 1.202, CI = 1.047-1.379, P = 0.009) were independently associated with presence of Tuberculosis.
conclusionThe prevalence of tuberculosis in Severe Acute Malnutrition was high. Children with SAM should be routinely screened for TB. When resources are constrained, the investigations for TB could be focused on those coming from rural areas, the HIV positive, those with thrombocytopenia and those with thrombocytosis.
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