ArticleParasites & vectors2025
Optimizing endectocide and ectocide compound evaluation in Anopheles malaria vectors.
Article in Parasites & vectors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMass endectocide or ectocide treatment of humans or livestock has been suggested as a possible malaria vector control tool. This work provides guidance for in vitro endectocide and ectocide experiments and raises biological points for further evaluation.
methodsThree experiments with ivermectin were performed with Anopheles dirus and Anopheles minimus. The first experiment assessed the impact of a sugar diet (10% sucrose, "Sucrose"; multivitamin syrup, "Multivitamin"; or multivitamin syrup followed by 10% sucrose, "Mix") on mosquito mortality following ingestion of a range of ivermectin-spiked blood meal concentrations. The lethal concentrations that kill 50% (LC
resultsThe Multivitamin diet was found to substantially increase An. dirus LC
conclusionsThe Mix diet appears to be best for minimizing control mosquito mortality, without altering the mosquito survival response following ivermectin ingestion. An unexplained biological phenomenon occurred when ivermectin was ingested in either a blood meal or a plasma meal. The concentration of ivermectin imbibed by the mosquito was lower than that observed in the blood meal, suggesting that some of the ivermectin may be excreted by the mosquito during the blood meal.
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