Evidence map›Paper›PMID 41107879›Full record

ArticleJournal of translational medicine2025

Pyrroloquinoline quinone targets senescent osteoclasts and reduces spinal pain and endplate degeneration in a lumbar spine instability mouse model.

Qinghe Geng, Yan Geng, Ke Heng, Juan Zhai, Xingchen Song, Liangwei Sha, Yinuo Geng, Peiru Nie, Fanshuo Liu, Huaiyuan Zhai and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

28 authors.

Qinghe GengKey Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China. Qinghegeng@xzhmu.edu.cn.ORCID 0000-0003-2073-1313
Yan Geng *Key Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China.
Ke Heng *Department of Orthopedics, Changzhou No. 2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, 213000, China.
Juan ZhaiKey Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China.
Xingchen SongKey Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China.
Liangwei ShaDepartment of Traditional Chinese Medicine, Pizhou Hospital of Traditional Chinese Medicine, Xuzhou, 221300, China.
Yinuo GengXuzhou Vocational College of Bioengineering, Xuzhou, 221300, China.
Peiru NieKangda College of Nanjing Medical University, Lianyun Gang, China.
Fanshuo LiuJiangsu Medical College, Yancheng, China.
Huaiyuan ZhaiKey Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China.
Junli HuangKey Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China.
Yanhong LiuKey Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China.
Mei LiKey Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China.
Guoqiang WangKey Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China.
Rui GengKey Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China.
Kui XueKey Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China.
Qilong WangKey Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China.
Wanying HuangKey Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China.
Shuangshuang SuoKey Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China.
Huanyu ZhangKey Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China.
Ying GengKey Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China.
Yuanji YangDepartment of Surgery, Xinghai People's Hospital, Xinghai, Qinghai, 813300, China.
Junyun LanDepartment of Surgery, Xinghai People's Hospital, Xinghai, Qinghai, 813300, China.
Hengsheng HuDepartment of Surgery, Xinghai People's Hospital, Xinghai, Qinghai, 813300, China.
Shengnan LiuKey Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China.
Xiangfei MengKey Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China.
Yilong GuoKey Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China. guoyilong888@163.com.
Jie LiDepartment of Orthopedics, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou Clinical College of Nanjing Medical University, Xuzhou, 221300, China. lijie87919@163.com.

Funding

Health Commission of Qinghai Province 2023-wjzdx-106Jiangsu Commission of Health Z2021046, LKM2022048, LSD2022014, LKM2024032Natural Science Foundation of Changzhou Municipality ZD202340Postdoctoral Research Foundation of China 2020M681739Xuzhou Medical University XZSYSKF2020004Xuzhou Science and Technology Program KC22273, KC22168Xuzhou Science and Technology Program XWKYHT20240010, 20240039
6 · The paper itself

Abstract

backgroundPyrroloquinoline Quinone (PQQ) is a redox cofactor with potent antioxidant and anti-inflammatory properties. This study investigated the therapeutic potential of PQQ in alleviating spinal pain and degeneration in a lumbar spine instability (LSI) mouse model. LSI is commonly associated with spinal pain and structural degeneration, with senescent osteoclasts (SnOCs) involved in spinal hypersensitivity and degeneration.

methodsLSI was induced in 8-week-old C57/BL6 mice by surgically resecting the L3–L5 spinous processes and associated ligaments. The mice were treated with PQQ, and behavioral tests (spinal hypersensitivity, anxiety, and activity levels) were conducted. Spinal endplate structural integrity was assessed through micro-computed tomography imaging and histological analyses. Immunohistochemical staining was performed to identify SnOCs and inflammatory markers.

resultsPQQ treatment significantly reduced pain-related hypersensitivity and anxiety behaviors in LSI mice. Behavioral improvements were demonstrated by increased activity, quicker heat response times, and reduced mechanical hypersensitivity. PQQ treatment also preserved the microarchitecture of spinal endplates by reducing endplate porosity, trabecular separation, and osteoclast activity. Additionally, PQQ reduced the number of SnOCs and modulated their inflammatory secretory phenotype, thereby decreasing sensory nerve innervation and angiogenesis in the spinal endplates.

conclusionsPQQ alleviates spinal pain and degeneration by targeting SnOCs, modulating inflammation, and preserving spinal microarchitecture. These findings suggest that PQQ has potential as a therapeutic agent for managing pain and structural degeneration in spinal instability-related disorders.

Indexed as

Cellular SenescenceLumbar VertebraeOsteoclastsPainPQQ CofactorAnimalsAnxietyBehavior, AnimalDisease Models, AnimalInflammationMaleMiceMice, Inbred C57BLX-Ray MicrotomographyPQQ CofactorAngiogenesisAnxiety behaviorsEndplate degenerationInflammationLumbar spine instability (LSI)Pyrroloquinoline Quinone (PQQ)Senescent osteoclasts (SnOCs)Sensory nerve innervationSpinal degenerationSpinal pain

Identifiers

PMID41107879
PMCPMC12535074

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.