ArticleBMC medical imaging2025
Multiparametric MRI assessment of acute neuroinflammation in a murine model of peripheral LPS stimulation.
Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundNeuroinflammation is implicated in the pathogenesis of several central nervous system disorders. Excessive and prolonged neuroinflammation impacts disease progression and potential interventions. A widely used model of peripherally-induced neuroinflammation involves the intraperitoneal administration of the endotoxin lipopolysaccharide (LPS) to mice. In this exploratory study, magnetic resonance imaging (MRI) was used to non-invasively investigate in the brain acute neuroinflammation induced by peripheral LPS stimulation and in combination with the microglia depleting effects of the colony stimulating factor 1 receptor kinase inhibitor BLZ945.
methodsMultiparametric MRI, including T
resultsOn day 4 of LPS administration, T
conclusionThe present findings highlight the potential of non-contrast-enhanced MRI to assess acute neuroinflammation-related changes in several mouse brain areas upon peripheral LPS stimulation. The assessment of multiple parameters provided sufficient sensitivity to detect pharmacological modulation of the neuroinflammatory response elicited by the endotoxin.
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