Evidence map›Paper›PMID 41107712›Full record

ArticleBMC genomics2025

DNA methylation landscape of Nautilus Pompilius.

Yueming Wu, Fan Mao, Xin Dang, Zhi Zhang, Ziniu Yu, Huawei Mu, Yang Zhang, Xiaoyuan Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yueming WuHefei National Laboratory for Physical Sciences at the Microscale, MOE Key Laboratory of Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, Anhui, China.
Fan MaoState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Key Laboratory of Tropical Marine Bioresources and Ecology, Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou, China.
Xin DangSwire Institute of Marine Science, School of Biological Sciences, The University of Hong Kong, Hong Kong, SAR, China.
Zhi ZhangHefei National Laboratory for Physical Sciences at the Microscale, MOE Key Laboratory of Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, Anhui, China.
Ziniu YuState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Key Laboratory of Tropical Marine Bioresources and Ecology, Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou, China.
Huawei MuHefei National Laboratory for Physical Sciences at the Microscale, MOE Key Laboratory of Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, Anhui, China. huaweimu@ustc.edu.cn.
Yang ZhangState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Key Laboratory of Tropical Marine Bioresources and Ecology, Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou, China. yzhang@scsio.ac.cn.
Xiaoyuan SongHefei National Laboratory for Physical Sciences at the Microscale, MOE Key Laboratory of Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, Anhui, China. songxy5@ustc.edu.cn.

Funding

National Key Research and Development Program of China 2022YFD2400301National Science Foundation of China 42449303National Science Foundation of China U22A20533Science and Technology Program of Guangzhou, China 2024A04J6278Young Elite Scientists Sponsorship Program by CAST 2023QNRC001
6 · The paper itself

Abstract

backgroundDNA methylation is a critical epigenetic modification that functions in diverse biological processes. High-throughput sequencing has revealed substantial variations in DNA methylation patterns across species. While extensively studied in vertebrates, knowledge of invertebrate DNA methylation remains limited.

resultsWe examined the DNA methylation landscape of the ancient-looking marine mollusk, Nautilus pompilius, a "living fossil". We identified key DNA methyltransferase genes (DNMT1 and DNMT3) by homologous searches against the N. pompilius genome and employed whole-genome bisulfite sequencing (WGBS) to characterize methylation patterns. Despite generally similar gene body methylation (gbM) and genome-wide methylation levels to other invertebrates, the N. pompilius exhibits a characteristic low methylation bias specifically in the promoter and first exon regions.

conclusionsN. pompilius has a typical gene body methylation pattern. Both promoter and gene body methylation may work together to regulate gene expression in N. pompilius. Our research provides valuable information to the ever-expanding methylation map of invertebrates.

Indexed as

DNA MethylationAnimalsCpG IslandsEpigenesis, GeneticPromoter Regions, GeneticDNA methylationNautilus PompiliusPhylogenetic comparisonWhole-genome bisulfite sequencing

Identifiers

PMID41107712
PMCPMC12532940

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.