Evidence map›Paper›PMID 41107660›Full record

ArticleScience China. Life sciences2026

Stroma-specific IL-15 coordinates epithelial IL-15Rα to promote intestinal epithelial repair.

Qihang Hou, Yong Zhang, Lihua Zhao, Yujiao Lai, Junyou Li, Yunshan Zhao, Yang Yang, Xin Yang, Xiaojun Yang, Bingkun Zhang

Abstract read
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In one paragraph

Article in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qihang Hou *State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science & Technology, China Agricultural University, Beijing, 100193, China.
Yong Zhang *Senior Department of General Surgery, the First Medical Center of Chinese PLA General Hospital, Beijing, 100853, China.
Lihua Zhao *State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science & Technology, China Agricultural University, Beijing, 100193, China.
Yujiao LaiState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science & Technology, China Agricultural University, Beijing, 100193, China.
Junyou LiGraduate School of Agricultural and Life Sciences, The University of Tokyo, Ibaraki, 319-0206, Japan.
Yunshan ZhaoDarkJade Sciences, Inc., Beijing, 100192, China.
Yang YangDarkJade Sciences, Inc., Beijing, 100192, China.
Xin YangCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Xiaojun YangCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Bingkun ZhangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science & Technology, China Agricultural University, Beijing, 100193, China. bingkunzhang@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin (IL)-15 is critical for intestinal homeostasis, but the precise origin and functions of IL-15 involved in inflamed mucosal healing are not fully understood. This study demonstrated that IL-15/IL-15Rα signaling was up-regulated during wound healing in 5-fluorouracil (5-FU)-induced intestinal mucositis. Moreover, a subset of podoplanin

Indexed as

Interleukin-15Interleukin-15 Receptor alpha SubunitIntestinal MucosaWound HealingAnimalsCell ProliferationEpithelial CellsFluorouracilHumansMiceMice, Inbred C57BLOrganoidsSignal TransductionSTAT3 Transcription FactorStromal CellsFluorouracilInterleukin-15Interleukin-15 Receptor alpha SubunitSTAT3 Transcription Factor5-FUIL-15/IL-15Rαintestinal stromal cellorganoidregeneration

Identifiers

PMID41107660

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.