Evidence map›Paper›PMID 41107646›Full record

ArticleAnnals of surgical oncology2026

Underutilization of Staging Laparoscopy Prior to Neoadjuvant Systemic Therapy in Gastric Cancer.

Arsha Ostowari, Kathryn T Chen, Bima J Hasjim, Stefania Montero, Shaina Sedighim, Fatemeh Tajik, Melanie Roman, Farshid Dayyani, Shaun Daly, Brian R Smith and 4 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Postoperative pain outcomes following thyroidectomy: a systematic review and network meta-analysis of various surgical approaches.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Pooled it
  2. Review
  3. Preservation of thyroid cartilage mobility via lateral cervical approach mitigates anterior neck dysfunction following hemithyroidectomy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Arsha OstowariDepartment of Surgery, University of California, Irvine Medical Center, Orange, CA, USA.
Kathryn T ChenDivision of Surgical Oncology, Department of Surgery, Harbor-UCLA Medical Center, Torrance, CA, USA.
Bima J HasjimDepartment of Surgery, University of California, Irvine Medical Center, Orange, CA, USA.
Stefania MonteroDepartment of Surgery, Harbor-UCLA Medical Center, Torrance, CA, USA.
Shaina SedighimDepartment of Surgery, University of California, Irvine Medical Center, Orange, CA, USA.
Fatemeh TajikDepartment of Surgery, University of California, Irvine Medical Center, Orange, CA, USA.
Melanie RomanDepartment of Surgery, University of California, Irvine Medical Center, Orange, CA, USA.
Farshid DayyaniDivision of Hematology/Oncology, Department of Medicine, University of California, Irvine Medical Center, Orange, CA, USA.
Shaun DalyChao Comprehensive Cancer Center, University of California, Irvine Medical Center, Orange, CA, USA.
Brian R SmithChao Comprehensive Cancer Center, University of California, Irvine Medical Center, Orange, CA, USA.
Ninh T NguyenChao Comprehensive Cancer Center, University of California, Irvine Medical Center, Orange, CA, USA.
Oliver S EngDivision of Surgical Oncology, Department of Surgery, University of California, Irvine Medical Center, Orange, CA, USA.
Michael P O'LearyDivision of Surgical Oncology, Department of Surgery, University of California, Irvine Medical Center, Orange, CA, USA.
Maheswari SenthilDivision of Surgical Oncology, Department of Surgery, University of California, Irvine Medical Center, Orange, CA, USA. m.senthil@uci.edu.ORCID http://orcid.org/0000-0002-0339-8558

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadiographically occult peritoneal carcinomatosis (PC) is a major concern in gastric cancer; hence staging laparoscopy (SL) is recommended prior to initiating treatment, particularly neoadjuvant systemic therapy (NST). However, compliance may vary and could result in understaging. We sought to evaluate the utilization of SL in patients with gastric cancer referred to academic institutions. PATIENTS AND

methodsThis is a multi-institution retrospective study of patients with a diagnosis of gastric/gastroesophageal junction (GEJ) Siewert 3 adenocarcinoma who received treatment between 2010 and 2022. Demographics, tumor characteristics, treatment, and recurrence data were collected. Descriptive statistics and multivariate analysis were performed.

resultsA total of 280 patients with gastric/GEJ cancer were identified, of which 75 (26.8%) had clinical stage IV disease and were excluded. Of the remaining 205 patients, 74 (36.1%) underwent upfront surgery and 131 (63.1%) underwent NST. Only 39 (29.8%) patients in the NST group underwent SL, of whom 15(38.4%) were found to have peritoneal metastases; 12 (80%) had gross PC and 3 (20%) had positive cytology. Among patients who underwent surgical resection after NST (n = 77), 26 (33.7%) experienced disease recurrence with a median time to recurrence of 11.6 months. The peritoneum (n = 10/26, 38.5%) was the most common site of recurrence.

conclusionsCompliance with SL prior to NST is poor (29.8%), and in the group that underwent SL, 38% of patients were upstaged due to presence of peritoneal metastases. These findings are significant, as the management and prognosis of peritoneal metastases are drastically different. Various factors could lead to poor compliance with SL, hence better compliance and alternate approaches to reliably detect PC are needed.

Indexed as

AdenocarcinomaLaparoscopyNeoadjuvant TherapyNeoplasm Recurrence, LocalPeritoneal NeoplasmsStomach NeoplasmsAdultAgedEsophagogastric JunctionFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm StagingPrognosisGastric cancerNeoadjuvant systemic therapyPeritoneal metastasesSiewert 3 gastroesophageal junction cancerStaging laparoscopy

Identifiers

PMID41107646
PMCPMC12765731

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.