Evidence map›Paper›PMID 41107635›Full record

ArticleBiological trace element research2026

Association Between Serum Copper and Overactive Bladder in Adults: A Cross-Sectional Study.

Mingming Xu, Qinghua Wang, Youyang Zhang, Yifan Liu, Hanchu Ye, Haopeng Li, Xin Qin, Yan Zhao, Wei Jiang, Xilei Li and 2 more

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Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Mingming Xu *Department of Urology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
Qinghua Wang *Department of Urology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
Youyang Zhang *Department of Geriatric Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Yifan LiuDepartment of Urology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
Hanchu YeDepartment of Urology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
Haopeng LiDepartment of Urology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
Xin QinDepartment of Urology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
Yan ZhaoDepartment of Urology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
Wei JiangDepartment of Urology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
Xilei LiDepartment of Urology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
Denglong WuDepartment of Urology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China. wudenglong2009@tongji.edu.cn.
Gang WuDepartment of Urology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China. 2013wg_urologist@tongji.edu.cn.

Funding

the Sixth Cycle of Institutional Key Disciplines of Shanghai Tongji Hospital ZD24-MN
6 · The paper itself

Abstract

Copper is one of the heavy metals that people are frequently exposed to in their daily lives and has been reported to be associated with a variety of diseases. However, the association between serum copper and the risk of overactive bladder (OAB) is currently unknown. The purpose of this study was to assess the potential risky association between serum copper and OAB in adults. A cross-sectional study involving 4600 adult participants from the National Health and Nutrition Examination Survey (NHANES) 2011-2016 was performed. OAB was assessed by the Overactive Bladder Symptom Score (OABSS). The association between serum copper and OAB was evaluated using univariate and multivariate weighted logistic regression models and subgroup analyses. Ultimately, 962 OAB participants and 3638 non-OAB participants were included. Serum copper concentrations were significantly higher in the OAB group compared to the non-OAB group (127.50 vs. 117.86). Univariate weighted logistic regression demonstrated that the highest tertile of serum copper was positively associated with the risk of OAB compared to the lowest tertile (OR = 2.761, 95% CI: 2.139-3.565, p < 0.001). Serum copper was still positively correlated with OAB after adjusting for all covariates (OR = 1.551, 95% CI: 1.140-2.109, p = 0.005). And the trend test was also statistically significant (p for trend = 0.004). Subgroup analyses indicated that the association between serum copper and OAB was significant in females (OR = 1.630, 95% CI: 1.064-2.497, p = 0.025). Excess serum copper is positively correlated with OAB risk, especially in females. The toxic effects of copper must be viewed with caution, and prospective cohort and mechanistic investigations are needed to validate the causal effects of copper on OAB.

Indexed as

CopperUrinary Bladder, OveractiveAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutrition SurveysCopperCopperNHANESOABSSOveractive bladder

Identifiers

PMID41107635

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.