ArticleScientific reports2025
Comparative evaluation of the cytotoxic effect of two different gutta percha solvents.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gutta percha solvents play an important role in removing filling materials from dentinal tubules, allowing irrigation solution to penetrate the tubules. The solvents should be biocompatible and have minimal effects on the viability of periapical tissues. Otherwise, they will result in intense inflammatory reactions and interfere with periapical healing. Aim This in vitro study was to evaluate and compare the cytotoxicity of two gutta percha solvents; grapefruit oil and orange oil. Biological testing was carried out on human fibroblasts that were retrieved from the cell bank and then cultured. Two gutta percha solvents (grapefruit oil and orange oil) were added to the cultured cells. Cell viability was evaluated using a WST-1 assay. The effect was evaluated after exposure to various concentrations at 24 h and 72 h. Statistical analysis was performed using two-way analysis of variance (ANOVA). Grapefruit oil had the most significant cytotoxicity followed by orange oil which had the least significant cytotoxicity. The cytotoxicity of the two solvents used was directly proportional to their concentration. Orange oil could be recommended as a solvent for gutta percha because of its low toxicity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.