Evidence map›Paper›PMID 41107398›Full record

ArticleScientific reports2025

ALZET pump implantation in mice for chronic drug delivery to the cochlea.

Frederic Depreux, Donna Whitlon, Claus-Peter Richter

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Frederic DepreuxDepartment of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Donna WhitlonDepartment of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Claus-Peter RichterDepartment of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA. cri529@northwestern.edu.

Funding

Office of Naval Research , Office of the Assistant Secretary of Defense for Health Affairs through the Hearing Restoration Research Program N000141210173; N000141512130; N000141612508; W81XWh-20-1-0484the APS by the USDOE, Basic Energy Sciences, Office of Science W-31-109-ENG-38
6 · The paper itself

Abstract

Drugs, chemical compounds, and other elements are often delivered to the ears of experimental animals to manipulate cochlear function, study how the ear works, identify drugs that prevent hearing loss, and test for ototoxicity. Delivery procedures for acute studies have been described in the literature. However, detailed information on methods that allow weeks of continuous drug delivery to the mouse cochleae is sparse. This paper describes a method for chronic drug delivery to the mouse cochlea. We illustrate the steps for the surgical implantation of an ALZET infusion pump and the placement of its catheter. We propose a ventral approach to the cochlea, using a surgical laser to make the cochleostomy and the placement of the pumps' delivery ports into scala tympani with an orientation toward the cochlear apex. The catheter's orientation toward the cochlear base often affects the vestibular system and is not favored for placement.

Indexed as

CochleaDrug Delivery SystemsInfusion Pumps, ImplantableAnimalsMiceBullostomyChronic implantationCochleostomyDrug deliveryMicro-osmotic pumpMouseSurgery

Identifiers

PMID41107398
PMCPMC12534686

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.