Evidence map›Paper›PMID 41107388›Full record

ArticleScientific reports2025

Mature CD209

André Ramon, Hélène Greigert, Baptiste Lamarthée, Corentin Richard, Alexis Varin, Claudie Cladière, Coraline Genet, Marion Ciudad, Noémie Klopfenstein, Roman Praliaud and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

André RamonDepartment of Rheumatology, Bourgogne-Europe University Hospital, Dijon, France. Andre.ramon@chu-dijon.fr.
Hélène GreigertEFS, INSERM UMR RIGHT, Marie et Louis Pasteur University, Besançon, France.
Baptiste LamarthéeEFS, INSERM UMR RIGHT, Marie et Louis Pasteur University, Besançon, France.
Corentin RichardMolecular Biology Unit, Georges-François Leclerc Cancer Center, UNICANCER, Dijon, France.
Alexis VarinEFS, INSERM UMR RIGHT, Marie et Louis Pasteur University, Besançon, France.
Claudie CladièreEFS, INSERM UMR RIGHT, Marie et Louis Pasteur University, Besançon, France.
Coraline GenetEFS, INSERM UMR RIGHT, Marie et Louis Pasteur University, Besançon, France.
Marion CiudadEFS, INSERM UMR RIGHT, Marie et Louis Pasteur University, Besançon, France.
Noémie KlopfensteinEFS, INSERM UMR RIGHT, Marie et Louis Pasteur University, Besançon, France.
Roman PraliaudEFS, INSERM UMR RIGHT, Marie et Louis Pasteur University, Besançon, France.
Guillaume BrenacEFS, INSERM UMR RIGHT, Marie et Louis Pasteur University, Besançon, France.
Georges TarrisDepartment of Pathology, Bourgogne-Europe University Hospital, Dijon, France.
Laurent MartinDepartment of Pathology, Bourgogne-Europe University Hospital, Dijon, France.
Louis ArnouldDepartment of Ophthalmology, Bourgogne-Europe University Hospital, Dijon, France.
Pierre-Henry GabrielleDepartment of Ophthalmology, Bourgogne-Europe University Hospital, Dijon, France.
Catherine Creuzot GarcherDepartment of Ophthalmology, Bourgogne-Europe University Hospital, Dijon, France.
Paul OrnettiDepartment of Rheumatology, Bourgogne-Europe University Hospital, Dijon, France.
Sylvain AudiaEFS, INSERM UMR RIGHT, Marie et Louis Pasteur University, Besançon, France.
Romain BoidotMolecular Biology Unit, Georges-François Leclerc Cancer Center, UNICANCER, Dijon, France.
Jean-Francis MaillefertDepartment of Rheumatology, Bourgogne-Europe University Hospital, Dijon, France.
Bernard BonnotteEFS, INSERM UMR RIGHT, Marie et Louis Pasteur University, Besançon, France.
Maxime SamsonEFS, INSERM UMR RIGHT, Marie et Louis Pasteur University, Besançon, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to characterize arterial dendritic cells (DCs) in polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). Bulk RNA-sequencing, RT-PCR and immunofluorescence analyses were performed from temporal arteries from GCA, PMR and control patients. Public single-cell RNA-seq (scRNA-seq) data on Peripheral Blood Mononuclear Cells (PBMCs) were analyzed from three GCA and three control patients. Bulk RNA-Seq and RT-PCR analyses demonstrated a high level of expression of DC lineage markers (CD209), DC maturation markers (CD83, CCR7) and chemokines associated with DC maturation in GCA arteries. The level of expression of DC lineage and DC maturation associated genes was significantly lower in PMR than in GCA arteries and similar between PMR and control arteries. GCA arteries expressed high levels of GM-CSF and IFNG mRNA. ScRNA-seq analysis of GCA PBMCs demonstrated high expression of IFNGR and CSF2R by classical monocytes and cultures of CD14

Indexed as

Antigens, CDCell Adhesion MoleculesDendritic CellsGiant Cell ArteritisLectins, C-TypeMonocytesReceptors, CCR7Receptors, Cell SurfaceAgedCell DifferentiationDC-Specific ICAM-3 Grabbing NonintegrinFemaleGranulocyte-Macrophage Colony-Stimulating FactorHumansMaleMembrane GlycoproteinsAntigens, CDCCR7 protein, humanCell Adhesion MoleculesDC-Specific ICAM-3 Grabbing NonintegrinGranulocyte-Macrophage Colony-Stimulating FactorLectins, C-TypeMembrane GlycoproteinsReceptors, CCR7Receptors, Cell SurfaceArterial wallDendritic cellGiant cell arteritisMaturationPolymyalgia rheumatica

Identifiers

PMID41107388
PMCPMC12534448

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.