Evidence map›Paper›PMID 41107340›Full record

ArticleScientific reports2025

HSP90/PUS7/THUMPD1 promotes metastasis and cisplatin resistance in gastric cancer cells.

Ziwei Ye, Junjie He, Renjie Zuo, Chenchun Ding, Zhenzhen Guo, Quan Liao, Xuan Zhu, Guoyan Liu, Li Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ziwei YeSchool of Pharmaceutical Sciences Xiamen University, Xiamen University, Xiamen, 361102, China.
Junjie HeSchool of Medicine Xiamen University, Xiamen University, Xiamen, 361102, China.
Renjie ZuoSchool of Medicine Xiamen University, Xiamen University, Xiamen, 361102, China.
Chenchun DingSchool of Medicine Xiamen University, Xiamen University, Xiamen, 361102, China.
Zhenzhen GuoSchool of Pharmaceutical Sciences Xiamen University, Xiamen University, Xiamen, 361102, China.
Quan LiaoSchool of Medicine Xiamen University, Xiamen University, Xiamen, 361102, China.
Xuan ZhuSchool of Pharmaceutical Sciences Xiamen University, Xiamen University, Xiamen, 361102, China.
Guoyan LiuDepartment of Gastrointestinal Surgery, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China. liuguoyan@xmu.edu.cn.
Li LinDepartment of Gastrointestinal Surgery, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361102, Fujian, China. 95511566@qq.com.

Funding

The Xiamen Natural Science Foundation of China 3502Z20227347
6 · The paper itself

Abstract

The metastasis and chemotherapy resistance of gastric cancer significantly contribute to treatment failure and mortality. Based on previous studies, we hypothesized that Heat Shock Protein 90 (HSP90) interacts with and upregulates Pseudouridine Synthase 7 (PUS7), which in turn promotes THUMP Domain Containing 1 (THUMPD1) expression, driving gastric cancer progression and drug resistance. Differential gene expression analysis revealed that HSP90, PUS7, and THUMPD1 are overexpressed in multiple tumor types and positively correlate with tumor mutational burden (TMB) and microsatellite instability (MSI). Mechanistically, HSP90 interacts with PUS7 to regulate THUMPD1 expression, enhancing tumor cell proliferation, migration, epithelial-mesenchymal transition (EMT), angiogenesis, and cisplatin resistance. Functional inhibition of HSP90 and THUMPD1 suppressed these oncogenic processes, while PUS7 overexpression exacerbated them. These findings highlight the HSP90/PUS7/THUMPD1 axis as a critical regulator of gastric cancer progression and a potential therapeutic target.

Indexed as

CisplatinDrug Resistance, NeoplasmHSP90 Heat-Shock ProteinsStomach NeoplasmsAnimalsCell Line, TumorCell MovementCell ProliferationEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansMiceNeoplasm MetastasisCisplatinHSP90 Heat-Shock ProteinsGastric cancerHSP90MechanismPUS7THUMPD1

Identifiers

PMID41107340
PMCPMC12534569

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.