Evidence map›Paper›PMID 41107295›Full record

ArticleScientific reports2025

KCa3.1 channels regulate the tumor infiltration of functionally competent NK cells in head and neck cancer.

Abdulaziz O Alshwimi, Ameet A Chimote, Marat V Khodoun, Layne Weatherford, Benjamin H Hinrichs, Heike Wulff, Stephen N Waggoner, Trisha M Wise-Draper, Laura Conforti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abdulaziz O AlshwimiDivision of Nephrology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA.
Ameet A ChimoteDivision of Nephrology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA.
Marat V KhodounDivision of Rheumatology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA.
Layne WeatherfordDivision of Hematology Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA.
Benjamin H HinrichsDepartment of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH, USA.
Heike WulffDepartment of Pharmacology, University of California Davis, Davis, CA, USA.
Stephen N WaggonerDepartment of Pediatrics, University of Cincinnati, Cincinnati, OH, USA.
Trisha M Wise-DraperDivision of Hematology Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA.
Laura ConfortiDivision of Nephrology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA. laura.conforti@uc.edu.

Funding

Hypoxia and Potassium Channel Activity in T LymphocytesR01CA095286 · NCI · UNIVERSITY OF CINCINNATI · PI CONFORTI, LAURA · 2003 to 2019
$4.1M
Liposome-based mRNA cancer immunotherapy targeting ion channelsR21CA277341 · NCI · UNIVERSITY OF CINCINNATI · PI CONFORTI, LAURA · 2023 to 2024
$405k
NCI NIH HHS R01 CA095286NCI NIH HHS R01CA95286NCI NIH HHS R21 CA277341
6 · The paper itself

Abstract

CD8

Indexed as

Head and Neck NeoplasmsIntermediate-Conductance Calcium-Activated Potassium ChannelsKiller Cells, NaturalSquamous Cell Carcinoma of Head and NeckAnimalsCell Line, TumorChemotaxisCytotoxicity, ImmunologicHumansMicePyrazolesTumor MicroenvironmentIntermediate-Conductance Calcium-Activated Potassium ChannelsKCNN4 protein, humanPyrazolesTRAM 34

Identifiers

PMID41107295
PMCPMC12534442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.