Evidence map›Paper›PMID 41107268›Full record

ArticleNature communications2025

Investigating the population structure of Moraxella catarrhalis using a cgMLST scheme and LIN code system.

Iman Yassine, Keith A Jolley, James E Bray, Melissa J Jansen van Rensburg, Fadheela Patel, Anna E Sheppard, Heather J Zar, Veronica Allen, Lemese Ah Tow, Martin C J Maiden and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Iman YassineNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1865-4179
Keith A JolleyDepartment of Biology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-0751-0287
James E BrayDepartment of Biology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-3554-4254
Melissa J Jansen van RensburgNuffield Department of Population Health, University of Oxford, Oxford, UK.
Fadheela PatelDivision of Medical Microbiology, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-5177-7416
Anna E SheppardNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-2913-0920
Heather J ZarDepartment of Paediatrics and Child Health, SA-MRC Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0002-9046-759X
Veronica AllenDivision of Medical Microbiology, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0002-3989-5513
Lemese Ah TowDivision of Medical Microbiology, University of Cape Town, Cape Town, South Africa.
Martin C J MaidenDepartment of Biology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-6321-5138
Mark P NicolDivision of Medical Microbiology, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0002-1366-4805
Angela B BrueggemannNuffield Department of Population Health, University of Oxford, Oxford, UK. angela.brueggemann@ndph.ox.ac.uk.ORCID http://orcid.org/0000-0002-2329-1934

Funding

The nasopharyngeal microbiome and respiratory disease in African childrenU01AI110466 · NIAID · UNIVERSITY OF CAPE TOWN · PI NICOL, MARK PATRICK, ZAR, HEATHER JOY · 2013 to 2016
$1.4M
Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation) OPP1017579Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation) OPP1017641NIAID NIH HHS U01 AI110466Wellcome TrustWellcome Trust (Wellcome) 206394/Z/17/ZWellcome Trust (Wellcome) 218205/Z/19/ZWellcome Trust (Wellcome) 221372/Z/20/Z
6 · The paper itself

Abstract

Moraxella catarrhalis is an important cause of infectious exacerbations of chronic obstructive pulmonary disease and otitis media. To investigate the population structure of M. catarrhalis, we developed a core-genome multilocus sequence typing (cgMLST) scheme using 1319 core genes, and a life identification number (LIN) barcode classification system. Whole-genome analyses of nearly 2000 genomes confirmed divergent seroresistant (SR) and serosensitive (SS) M. catarrhalis lineages with distinct evolutionary trajectories. SR genomes are more conserved, while SS genomes exhibited greater genetic variability. Virulence gene analyses revealed lineage-specific variations in ubiquitous surface proteins (UspA1 and UspA2) and lipooligosaccharide (LOS) types. The bro β-lactamase, and mcb bacteriocin cluster, are more common in SR lineages, which suggested different selective pressures and adaptation. Here, we show that this cgMLST scheme and LIN code system provide a robust method for characterising M. catarrhalis, distinguish between SR and SS lineages, and offer a unified framework for population structure analyses.

Indexed as

Moraxella catarrhalisMultilocus Sequence TypingBacterial ProteinsEvolution, MolecularGenetic VariationGenome, BacterialHumansMoraxellaceae InfectionsPhylogenyBacterial Proteins

Identifiers

PMID41107268
PMCPMC12534458

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.