SynthesisTranslational psychiatry2025
The association between white matter hyperintensities and suicide attempts in affective disorders: a systematic review and meta-analysis.
Synthesis in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Edge-centric brain connectomes reveal two molecularly distinct neurobiological subtypes of adolescent major depressive disorder.European child & adolescent psychiatry · 2026Article
- White Matter Hyperintensities and Clinical Phenotype in Late-Onset Psychiatric Disorders: A Multidimensional Clinical-Neuroimaging Study.Neurology international · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A growing body of literature examines the neurobiological bases of suicidal behaviors, including the potential relationship between white matter hyperintensities (WMHs) and a history of suicide attempts in patients with affective disorders. We aimed to synthesize these studies, evaluate their quality, and provide recommendations for future research. We conducted a comprehensive literature search using three approaches: (i) search across PubMed, PsycINFO, Scopus, and Web of Science until October 2024; (ii) screening of previous reviews and meta-analyses; and (iii) citation mining of the included studies. The PRISMA guidelines were followed, and a random-effects meta-analysis was performed to calculate pooled Odds Ratios (OR). Sixteen studies were included in the systematic review, involving 1393 participants. Of these, 8 were also included in the meta-analysis. The main analyses revealed an association between WMHs (either deep or periventricular hyperintensities), and a history of suicide attempts in individuals with major depressive disorder (OR = 2.15, 95% confidence interval (CI) 1.03 - 4.49) and bipolar disorders (OR = 2.15, 95% CI 0.89 - 5.20). The main limitations concern the small number of studies, the degree of heterogeneity among the lesion rating systems adopted, and the lack of data on the severity of WMHs. Also, only some of the studies controlled for key confounding variables that may influence results. Overall, we found that individuals with affective disorders who had WMHs, particularly periventricular rather than deep white matter hyperintensities, were more likely to have attempted suicide in their lifetime, suggesting a potential role as neurobiological markers for suicide attempts.
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