ArticleNature communications2025
Chronic 40 Hz light flicker mitigates epileptogenesis through a visual pathway associated with the dorsal lateral geniculate nucleus shell.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- High intensity 40 Hz flicker improves amyloid pathology and cognition with autophagy in 3xTg mice.iScience · 2026Article
- Intraoperative 40 Hz gamma frequency auditory stimulation for postoperative sleep disturbance in patients undergoing laparoscopic gynecological surgery: protocol for a randomized controlled trial.Frontiers in medicine · 2026Article
- Light-based 40 Hz sensory therapy for brain disorders: physiological basis, therapeutic mechanisms, and future prospects.Frontiers in medicine · 2026Review
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Authors and funding
15 authors.
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Abstract
Altered gamma activity is associated with epilepsy. Gamma entrainment using sensory stimuli (GENUS), a non-invasive, exogenous stimulation by rhythmic 40 Hz light flicker, strengthens gamma activity in the primary visual cortex (V1) and suppresses spike generation. Here, we assessed the effect of GENUS on epileptogenesis in male mice with status epilepticus induced by pilocarpine. We found that GENUS immediately increased gamma activity and reduced epileptiform spikes in epileptic mice. After six weeks of GENUS treatment in epileptic mice, significant reductions were observed in neuronal loss and gliosis, brain hyperexcitability was ameliorated, and epilepsy-related behavioral performance was improved. We determined that the increased 40 Hz oscillations and reduced seizure susceptibility induced by GENUS were dependent on the visual circuit associated with ON-OFF direction-selective retinal ganglion cells, glutamatergic neurons in the shell of the dorsal lateral geniculate nucleus, and parvalbumin-expressing fast-spiking interneurons in the superficial 2/3 layer of V1.
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