ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2026
Brain White Matter Microstructure in Middle and Older Aged Adults With Bipolar Disorder: A 2-Site Study.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Brain alteration of PCOS: neuroimaging and function.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectiveAdolescents and adults with bipolar disorder (BD) show white matter (WM) microstructural alterations in tracts important for emotion regulation and cognition, including the anterior corpus callosum, cingulum, and uncinate fasciculus. Less is known about WM microstructure in middle age and older adults with BD (MOABD), although they often have substantial mood symptoms, cognitive impairments, and suicide and dementia risk. The present study investigated WM microstructure in MOABD and its relationship with age. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: In a 2-site diffusion tensor imaging study of adults ages 40-79 years (primary sample: n = 88 MOABD, 93 age-comparable non-psychiatric adults (NP); confirmatory sample: n = 29 MOABD, 47 NP). WM fractional anisotropy (FA) in the corpus callosum, cingulum, and uncinate fasciculus were compared between groups. Furthermore, diagnosis by age interaction analysis was performed.
resultsAcross both sites, relative to NP, MOABD showed significantly lower FA throughout corpus callosum and in left cingulum (p < 0.05, multiple comparisons-corrected). Lower FA in the bilateral uncinate was observed, significant at the primary site and with a similar effect size at the confirmatory site. Diagnosis by age interactions were not significant.
conclusionsThe results support abnormalities in inter- and intra-hemispheric WM tracts connecting regions that subserve emotion regulation and cognition in MOABD, consistent with findings in younger cohorts with BD. Findings in the posterior corpus callosum suggest a greater extent of alterations in MOABD that may contribute to their phenotype, while findings in other regions align with prior research suggesting early WM neurodevelopmental alterations that persist into older adulthood.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.