Evidence map›Paper›PMID 41107067›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Dysfunction of Unc119, a Transducin-Binding Protein, Leads to Cone-Rod Dystrophy through Activating JAK-Stat and NF-κB Inflammatory Pathways in the Mouse Retina.

Koki Kobayashi, Taro Chaya, Hung-Ya Tu, Yamato Maeda, Yuki Nakashima, Ryotaro Tsutsumi, Haruka Yamamoto, Toshinori Tsujii, Daisuke Okuzaki, Takahisa Furukawa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Koki KobayashiLaboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan.ORCID 0009-0002-5936-6229
Taro ChayaLaboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan.ORCID 0000-0001-5562-8733
Hung-Ya TuLaboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan.
Yamato MaedaLaboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan.
Yuki NakashimaLaboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan.
Ryotaro TsutsumiLaboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan.
Haruka YamamotoLaboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan.
Toshinori TsujiiLaboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan.
Daisuke OkuzakiGenome Information Research Center, Research Institute for Microbial Diseases, The University of Osaka, Osaka 565-0871, Japan.
Takahisa FurukawaLaboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan takahisa.furukawa@protein.osaka-u.ac.jp.ORCID 0000-0003-4171-220X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transducin is a heterotrimeric G-protein that is a component of the phototransduction cascade in rod and cone photoreceptor cells of the retina. Gnat1, a rod-specific transducin α-subunit, regulates light/dark adaptation by changing its subcellular localization depending on light. Our previous study revealed that Gnat1 translocation in rod photoreceptor cells under light/dark conditions requires E3 ligase Klhl18-mediated ubiquitination and degradation of Unc119, a Gnat1-binding protein. A mutation in the human

Indexed as

Adaptor Proteins, Signal TransducingCone-Rod DystrophiesInflammationRetinaSignal TransductionAnimalsEye ProteinsFemaleHEK293 CellsHeterotrimeric GTP-Binding ProteinsHumansJanus KinasesMaleMembrane ProteinsMiceMice, Inbred C57BLAdaptor Proteins, Signal TransducingEye ProteinsGnat2 protein, mouseHeterotrimeric GTP-Binding ProteinsJanus KinasesMembrane ProteinsNF-kappa BSTAT Transcription FactorsUnc119 protein, mouse

Identifiers

PMID41107067
PMCPMC12660177

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.