ArticleOpen heart2025
Causal relevance of clonal haematopoiesis with cardiac disease and adverse remodelling: a Mendelian randomisation study.
Article in Open heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Clonal hematopoiesis of indeterminate potential (CHIP), vascular somatic mutation, and cardiovascular disease: A narrative review.Vascular medicine (London, England) · 2026Review
- Statin Use and Genetically Predicted HMG-CoA Reductase Inhibition in Relation to Clonal Hematopoiesis.medRxiv : the preprint server for health sciences · 2026Article
- Clonal haematopoiesis and cardiovascular disease, defining risk, filling gaps, and framing the future.NPJ cardiovascular health · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundMany observational studies highlight clonal haematopoiesis (CH) as a novel determinant of cardiovascular disease (CVD). However, disentangling cause and effect from important confounders, such as age and smoking, is challenging.
objectivesMendelian randomisation (MR) was used to assess the causal relationships of CH with (1) major CVD outcomes associated with adverse remodelling, and (2) cardiovascular magnetic resonance (CMR) phenotypes which have not been examined previously.
methodsUncorrelated (r
resultsBoth
conclusionsCommon forms of CH are associated with higher AF risk and adverse remodelling patterns comprising larger atrial and ventricular sizes, myocardial fibrosis, and reduced aortic compliance. Using MR methods, this study triangulates previous observational studies and provides new evidence to support likely causal links between CH and CVD. This study, for the first time, describes associations of CH with adverse CMR phenotypes suggesting early remodelling patterns; these changes may indicate a window of opportunity for intervention such as by risk stratification and early preventative strategies to improve patient outcomes; however, further examination of the utility of such interventions is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.