Evidence map›Paper›PMID 41106907›Full record

ReviewDental clinics of North America2025

Artificial Intelligence in Endodontics/Robotics- Microrobotics in Endodontics: A Revolutionary Approach to Root Canal Treatment and Nanozymes.

Nadasinee Jaruchotiratanasakul, Hong Huy Tran, Edward B Steager, Hyun Koo, Bekir Karabucak

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Dental clinics of North America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nadasinee JaruchotiratanasakulDepartment of Endodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Innovation & Precision Dentistry, School of Dental Medicine, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA; Biofilm Research Laboratories, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Operative Dentistry and Endodontics, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand.
Hong Huy TranBiofilm Research Laboratories, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Orthodontics, Division of Pediatric Dentistry and Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Chemical and Biomolecular Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA.
Edward B SteagerCenter for Innovation & Precision Dentistry, School of Dental Medicine, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA; Biofilm Research Laboratories, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; GRASP Laboratory, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Hyun KooCenter for Innovation & Precision Dentistry, School of Dental Medicine, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA; Biofilm Research Laboratories, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Orthodontics, Division of Pediatric Dentistry and Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Bekir KarabucakDepartment of Endodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: bekirk@upenn.edu.

Funding

Biofilm Elimination and Caries Prevention using Multifunctional NanocatalystsR01DE025848 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI KOO, HYUN · 2017 to 2025
$5.6M
Small Scale Robotics for Automated Dental Biofilm TheranosticsR01DE031491 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI KOO, HYUN, STEAGER, EDWARD · 2023 to 2025
$1.9M
Small Scale Robotics for Automated Dental Biofilm TreatmentR56DE029985 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI KOO, HYUN, STEAGER, EDWARD · 2021 to 2021
$656k
NIDCR NIH HHS R01 DE025848NIDCR NIH HHS R01 DE031491NIDCR NIH HHS R56 DE029985
6 · The paper itself

Abstract

This article explores cutting-edge innovations in endodontic care, emphasizing the role of microrobotics and nanozymes in overcoming persistent challenges like biofilm eradication and effective root canal disinfection. Nanozyme-shelled microcapsules and advanced robotic systems enable precise navigation, biofilm removal, and therapeutic delivery in complex dental structures, reducing reinfection rates and improving treatment outcomes. While these technologies offer transformative potential, challenges-such as biocompatibility, fabrication complexities, and clinical integration-remain. This article highlights ongoing research and future opportunities to integrate these advancements into routine care, paving the way for minimally invasive, efficient, and regenerative approaches in endodontic therapy.

Indexed as

Artificial IntelligenceEndodonticsRoboticsRoot Canal TherapyBiofilmsHumansAdvanced technologyMicroroboticsNanozymesRobotics in endodonticsRoot canal disinfectionRoot canal treatment

Identifiers

PMID41106907
PMCPMC12866934

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.