Evidence map›Paper›PMID 41106900›Full record

ArticleJACC. Case reports2025

Alpha-Gal Syndrome and Aortic Valve Replacement.

Nabeel Sami, Bharat Ravishankar, Berhane Worku, Diana Khatib, Erin McGintee, Terrence Sacchi, Ozgen Dogan, Gila Perk, Mark Reisman, Nino Mihatov

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nabeel SamiDivision of Cardiology, Department of Medicine, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, USA.
Bharat RavishankarDivision of Cardiology, Department of Medicine, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, USA.
Berhane WorkuDepartment of Cardiothoracic Surgery, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, USA; Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, New York, USA.
Diana KhatibDivision of Cardiac Anesthesiology, Weill Cornell Medical College, New York, New York, USA.
Erin McGinteeENT and Allergy Associates, Southampton, New York, USA.
Terrence SacchiDivision of Cardiology, Department of Medicine, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, USA.
Ozgen DoganDivision of Cardiology, Department of Medicine, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, USA.
Gila PerkDivision of Cardiology, Department of Medicine, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, USA; Division of Cardiology, Department of Medicine, Weill Cornell Medical College, New York, New York, USA.
Mark ReismanDivision of Cardiology, Department of Medicine, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, USA; Division of Cardiology, Department of Medicine, Weill Cornell Medical College, New York, New York, USA.
Nino MihatovDivision of Cardiology, Department of Medicine, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, USA; Division of Cardiology, Department of Medicine, Weill Cornell Medical College, New York, New York, USA. Electronic address: nim9139@med.cornell.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlpha-gal syndrome (AGS) is an IgE-mediated hypersensitivity response to galactose-alpha-1,3-galactose (alpha-gal), an oligosaccharide present in beef and pork. This complicates bioprosthetic heart valve selection, as both bovine and porcine valves contain alpha-gal, posing risks of allergic reaction and potentially accelerated structural valve degeneration. CASE SUMMARY: A 78-year-old man with AGS and severe symptomatic aortic stenosis underwent transcatheter aortic valve replacement with a porcine-derived Evolut FX 29-mm valve following multidisciplinary evaluation. Preoperative allergist-guided prophylaxis, including IgE risk stratification, antihistamines, and corticosteroids, enabled successful implantation without complications. DISCUSSION: Bioprosthetic valves may pose unique risks for individuals sensitized to alpha-gal, where an alpha-gal IgE to total IgE ratio ≤5% is a proposed threshold in which patients can be rechallenged with animal products. This case highlights the successful management of a slightly higher ratio. TAKE-HOME MESSAGE: The interplay between AGS, bioprosthetic valve selection, and structural valve durability necessitates an individualized approach to mitigate the hypersensitivity risks.

Indexed as

aortic valvecardiac riskDoppler ultrasoundechocardiographystenosisvalve replacement

Identifiers

PMID41106900
PMCPMC12793876

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.