ArticleJACC. Case reports2025
Echocardiographic Evidence of Clozapine-Induced Myocarditis With Pericardial Involvement in a Young Woman.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
backgroundMyocarditis is a rare adverse effect of clozapine, often occurring within the first month of use. CASE SUMMARY: We present a case of an 18-year-old woman who developed recurrent somnolence, orthostatic hypotension, and elevated troponins days after starting a clozapine induction, while also on valproic acid. Transthoracic echocardiogram (TTE) revealed a reduced left ventricular ejection fraction and symmetric left ventricular wall thickening concerning for myocardial edema, as well as a pericardial effusion. Clozapine was promptly withdrawn, and the patient was started on colchicine. Follow-up TTE showed improved left ventricular ejection fraction and resolution of left ventricular wall thickening. DISCUSSION: Clozapine-induced myocarditis presents with elevated troponins and inflammatory markers; however, myocardial involvement may not always be detectable by TTE. Medication withdrawal and supportive care are the cornerstone of initial treatment. TAKE-HOME MESSAGE: This case highlights the significant effects that clozapine can have on the myocardium, especially with concurrent use of valproic acid.
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