Evidence map›Paper›PMID 41106692›Full record

ReviewNeurobiology of disease2025

Tubular ER dysfunction in neurodegenerative diseases.

Md Golam Sharoar, Riqiang Yan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurobiology of disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Md Golam SharoarAlzheimer's disease Research Program, Corewell Health Research Institute (CHRI), Corewell Health East, 3811 W 13 Mile Road, Royal Oak, MI 48073, United States of America; Department of Internal Medicine, Oakland University William Beaumont School of Medicine (OUWB), Corewell Health East, 3811 W 13 Mile Road, Royal Oak, MI 48073, United States of America. Electronic address: mdgolam.sharoar@corewellhealth.org.
Riqiang YanDepartment of Neuroscience, University of Connecticut Health, 263 Farmington Ave, Farmington, CT 06030, United States of America. Electronic address: riyan@unch.edu.

Funding

Roles of reticulon proteins in neurodegenerative disordersR01AG025493 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI YAN, RIQIANG · 2005 to 2024
$5.9M
Supplement for BACE1 in neurodegeneration and neuronal dysfunctionR01NS074256 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI RIQIANG YAN · 2011 to 2026
$5.8M
Role of the CX3CL1 C-terminus in reversing age-dependent Alzheimers neurodegenerationRF1AG058261 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI YAN, RIQIANG · 2017 to 2023
$5.0M
Inhibition of BACE1 for benefiting Alzheimer's patientsR01AG046929 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI RIQIANG YAN · 2013 to 2026
$3.9M
Inhibition of BACE1 for benefiting Alzheimer's patientsRF1AG046929 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI YAN, RIQIANG · 2018 to 2018
$3.3M
Roles of reticulon proteins in neurodegenerative disordersRF1AG025493 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI YAN, RIQIANG · 2020 to 2020
$3.0M
BACE1 in neurodegeneration and neurological dysfunctionRF1NS074256 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI YAN, RIQIANG · 2021 to 2021
$2.1M
NIA NIH HHS R01 AG025493NIA NIH HHS R01 AG046929NIA NIH HHS RF1 AG025493NIA NIH HHS RF1 AG046929NIA NIH HHS RF1 AG058261NINDS NIH HHS R01 NS074256NINDS NIH HHS RF1 NS074256
6 · The paper itself

Abstract

Endoplasmic reticulum (ER) is the largest secretory organelle, and it regulates diverse cellular processes to support neuronal growth, development, and maintenance during the lifespan. Structural alterations to the ER network affect a multitude of functions and downstream events, which result in abnormalities in neuronal maintenance and neuronal death. Morphological and functional abnormalities in the tubular domain of ER or in tubular ER proteins have been linked to several major neurodegenerative diseases, including Alzheimer's disease (AD) and hereditary spastic paraplegias (HSPs). Tubular ER dysfunction in neurodegenerative diseases is manifested by elevated expression, abnormal aggregation, haplo-insufficiency, or functional deficiency in multiple ER tubule-shaping proteins. This review aims to highlight the involvement of ER tubule shaping and networking proteins that cause tubular ER dysfunction in AD and HSPs. The discussion of this review will also highlight the functional necessity of an integrated tubular ER network for axonal maintenance.

Indexed as

Endoplasmic ReticulumNeurodegenerative DiseasesAnimalsHumansAlzheimer's diseaseDystrophic neuriteHereditary spastic paraplegiaMitochondria dysfunctionTubular endoplasmic reticulumTubular ER clustering

Identifiers

PMID41106692
PMCPMC12616734

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.