Deletion or enhancement of alpha-2 nAChRs (Chrna2) induces unique lifespan behavioral deficits.

Alicia C Wells, Celina Mojica, Christie D Fowler, Shahrdad Lotfipour

Abstract read

In one paragraph

Article in Neuropharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alicia C WellsSchool of Medicine, University of California, Irvine, CA, USA. Electronic address: wellsac1@uci.edu.

Celina MojicaGraduate Division, University of California, Irvine, CA, USA.

Christie D FowlerDepartment of Neurobiology and Behavior, University of California, Irvine, CA, 92697, USA.

Shahrdad LotfipourSchool of Medicine, University of California, Irvine, CA, USA; Department of Emergency Medicine, Pharmaceutical Sciences, Pathology and Laboratory Medicine, University of California, Irvine, CA, 92697, USA.

Funding

Institute for Clinical and Translational ScienceUM1TR004927 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAN M COOPER, Eric J. Vilain · 2024 to 2026

$12.2M

NCATS NIH HHS UM1 TR004927

6 · The paper itself

Abstract

Exposure to nicotine is known to have unique lifespan effects, with sexual dimorphisms suggested to exist in learning and memory during both adolescence and adulthood. Using a fear conditioning paradigm, we assessed whether genetic manipulation of the Chrna2 gene (Chrna2

Indexed as

Receptors, NicotinicAnimalsBehavior, AnimalExtinction, PsychologicalFearFemaleMaleMiceMice, Inbred C57BLMice, KnockoutNicotineNicotinic AgonistsSex CharacteristicsCHRNA2 protein, mouseNicotineNicotinic AgonistsReceptors, NicotinicAdolescenceChrna2KnockoutnAChRNicotineSexual dimorphism

Identifiers

PMID41106540

DOI10.1016/j.neuropharm.2025.110725

PMCPMC13058822

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.